Maurice Pechet Explained

Maurice Pechet
Birth Date:February 10, 1918
Birth Place:Saskatchewan, Canada
Death Place:Cambridge, Massachusetts
Alma Mater:Harvard University
Citizenship:American
Spouse:Kitty Pechet

Maurice Pechet (February 10, 1918 – March 5, 2012) was a professor, scientist, doctor, inventor, and philanthropist.[1] Pechet made substantial contributions to the field of internal medicine, in particular in the domain of developing new antirachitic sterols to treat metabolic bone disease.[2] He resided in Cambridge, Massachusetts for most of his life. At Harvard University, he was a student (earning both a chemistry PhD in 1944 and MD in 1948), professor, and doctor (Massachusetts General Hospital), and was involved with the campus for 70 years.[1]

Medical discoveries

Pechet and his research partners are credited with the discovery of the Pechet Factor Deficiency (OMIM:169200), a genetic disorder causing an abnormal blood clotting defect in a sister, brother and mother. Pechet and his research partners suggested that these persons lack a clotting factor that plays a role in the first phase of coagulation, following the activation of factor IX but before the activation of factor X.[3] [4] [5]

Publications

Pechet has been widely published in leading medical journals, such as the New England Journal of Medicine,[6] the American Journal of Medicine,[7] [8] the Journal of Clinical Investigation,[9] and the Journal of Pediatrics.[10]

Leadership roles

Personal life

Pechet was married to artist and teacher Kitty Pechet. She continues to reside in Cambridge, Massachusetts.

Philanthropy

Pechet donated to a wide range of philanthropic causes.In 1960, he established the Pechet Foundation.[15] The Pechet Foundation has given to scientific research, poverty alleviation, education, the arts, and environmental causes. The Foundation has made donations and provided grants to such organizations as the Golden Foundation for the Arts, the Earthwatch Institute, The Cambridge Family & Children's Service, The Young Audiences of Massachusetts,[16] The New Sector Alliance,[17] The Cambridge Center for Adult Education, The Breast Cancer Research Foundation, The Perkins School for the Blind, The Center for Blood Research (CBR), and the New England Conservatory.

Business activities

Pechet was a Director Emeritus of the Canadian Western Bank.

External links

Notes and References

  1. Web site: Maurice M. Pechet Obituary . ObitsforLife . 8 March 2012 . dead . https://web.archive.org/web/20150602083602/http://obitsforlife.com/obituary/485790/Pechet-Maurice-M.php . 2 June 2015 .
  2. Web site: The American Society for Clinical Investigation.
  3. Web site: OMIM Entry (169200): Pechet Factor Deficiency. Online Mendelian Inheritance in Man® An Online Catalog of Human Genes and Genetic Disorder. OMIM®, Johns Hopkins University. 15 December 2015.
  4. Web site: Pechet Factor Deficiency. Comparative Toxicogenomics Database. MDI Biological Laboratory & NC State University. 15 December 2015.
  5. Web site: National Library of Medicine - Medical Subject Headings: Pechet Factor Deficiency. U.S. National Library of Medicine. 15 December 2015.
  6. Response of Adult Patients with Osteomalacia to Treatment with Crystalline 1α-Hydroxy Vitamin D3 291:866-871 October 24, 1974. New England Journal of Medicine. 291. 17. 866–871. Philippe Bordier, M.D., Maurice M. Pechet, M.D., Robert Hesse, Pierre Marie, and Howard Rasmussen, M.D.. The New England Journal of Medicine. 10.1056/NEJM197410242911702. 4415589. 1974.
  7. Metabolic and clinical effects of pure crystalline 1α-hydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3. 57. 13–20. Maurice M. Pechet, M.D., Robert H. Hesse. The American Journal of Medicine. 10.1016/0002-9343(74)90762-1. 1974.
  8. Regulation of bone resorption and formation. 43. 5. 696–710. Maurice M. Pechet, M.D., Eduardo Bobadilla, M.D., Evelyn L. Carroll, A.B., Robert H. Hesse. The American Journal of Medicine. 10.1016/0002-9343(67)90112-X. 6054839. 1967.
  9. METABOLIC STUDIES WITH A NEW SERIES OF 1,4-DIENE STEROIDS. II. EFFECTS IN NORMAL SUBJECTS OF PREDNISONE, PREDNISOLONE, AND 9α-FLUOROPREDNISOLONE, Published in Volume 38, Issue 4 (April, 1959). Journal of Clinical Investigation. 38. 4. 691–701. Maurice M. Pechet, Blair Bowers and Frederic C. Bartters. The Journal of Clinical Investigation. 10.1172/JCI103848. 13641421. 293209. 1959.
  10. Long-term treatment of familial hypophosphatemic rickets with oral phosphate and 1α-hydroxyvitamin D3. 99. 1. 16–25. M.D. Howard Rasmussen. M.D. Maurice Pechet. The Journal of Pediatrics. M.D. Constantine Anast. R.N. Alice Mazur. M.D. Joseph Gertner. M.D. Arthur E. Broadus. 6265614. 1981. 10.1016/S0022-3476(81)80951-1.
  11. Web site: Harvard Medical School Board of Fellows. Harvard Medical School Website.
  12. Web site: Board of Tutors in Biochemical Sciences. dead. https://web.archive.org/web/20100703072154/http://www.mcb.harvard.edu/UndergradStudy/Biochem/Tutors.asp. 2010-07-03.
  13. Web site: Canadian Western Bank (CWB:TSX) Company Profile. BloombergBusinessweek.
  14. Web site: A look inside: Lowell House, Defined by a Harvard family, creating a larger one. Harvard Gazette. 2011-10-27.
  15. Web site: The National Center for Charitable Statistics (NCCS). 2011-01-05. https://web.archive.org/web/20110725063506/http://nccsdataweb.urban.org/orgs/profile/046059253?popup=1#overview. 2011-07-25. dead.
  16. Web site: The Young Audiences of Massachusetts: Community Partners and Benefactors. dead. https://web.archive.org/web/20100718115356/http://www.yamass.org/commpart.htm. 2010-07-18.
  17. Web site: The New Sector Alliance: Current and past supporters of New Sector. dead. https://web.archive.org/web/20100712203903/http://www.newsector.org/partners/investors.php. 2010-07-12.

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