Matthew Todd (chemist) explained

Matthew H. Todd
Birth Name:Matthew Houghton Todd
Birth Date:1973 1, df=y
Birth Place:Manchester, United Kingdom
Residence:Greenwich, London, United Kingdom -->
Alma Mater:University of Cambridge
Thesis Title:Novel encoding strategies for combinatorial chemistry
Thesis Url:https://www.repository.cam.ac.uk/handle/1810/272807
Thesis Year:1998
Doctoral Advisor:Chris Abell
Academic Advisors:Paul A. Bartlett
Notable Students:Alice Motion
Known For:Open Source Malaria
Open Source Tuberculosis
Open Source Mycetoma
Website:The Todd Group

Matthew Houghton Todd (born 13 January 1973) is a British chemist and the Professor and Chair of Drug Discovery of the School of Pharmacy at University College London.[1] He is the founder of Open Source Malaria (OSM) and his research focuses on drug discovery and development for this disease.[2] [3] [4] [5] [6] Recently, he has expanded to other areas, particularly neglected diseases such as tuberculosis and mycetoma[7] in the Open Source Tuberculosis (OSTB) and Open Source Mycetoma (MycetOS) project, through a collaboration with the Drugs for Neglected Diseases Initiative and Erasmus MC.[8] In addition, he has some research activity in catalysis and methodology.[9] [10] [11] [12]

Education

Todd received an MA in Natural Sciences from the University of Cambridge in 1995. He obtained his PhD in Organic Chemistry at the same institution in 1999, working with Chris Abell on encoding and linker strategies for combinatorial chemistry.[13] [14] [15] [16] Todd was a Wellcome Trust Postdoctoral Research Fellow at the University of California, Berkeley from 1999 to 2000, working with Paul A. Bartlett on synthesis of amino acid-derived heterocycles by Lewis acid catalysis and radical cyclisations from peptide acetals.[17] [18]

Career and research

From 2000 to 2001, he was a College Fellow and Lecturer at New Hall, Cambridge (now Murray Edwards College, Cambridge). He began his independent research career in 2001 at Queen Mary University of London. In 2005, he relocated to Australia where he was a lecturer, senior lecturer, then associate professor at the School of Chemistry, University of Sydney. In 2018, he returned to the United Kingdom to take the role of professor and Chair of Drug Discovery at UCL School of Pharmacy.[1]

In response to the price hike of HIV/AIDS drug, pyrimethamine (Daraprim), by Turing Pharmaceuticals,[19] Todd and the Open Source Malaria team led a small team of high school students from Sydney Grammar School to synthesise the drug.[20] [21] The students produced 3.7 grams of pyrimethamine for US$20, which would be worth between US$35,000 and US$110,000 in the United States based on hiked prices.[22] This received significant media attention and was featured on ABC, BBC,[23] CNN,[24] The Guardian, and Time.[25]

Todd has been a vocal proponent of open science and open research.[26] [27] [28] [29] In 2011, he proposed Six Laws of Open Research to guide present and future open research projects including OSM and MycetOS:[30] [31] [32] [33]

Todd is on the Editorial boards of Chemistry Central Journal,[34] ChemistryOpen,[35] PLOS One,[36] Scientific Reports,[37] and Scientific Data.[38]

Honours and awards

See also

External links

Notes and References

  1. Web site: Professor Matthew Todd – UCL School of Pharmacy . 2 October 2018 .
  2. News: Peplow . M . Open-source drug discovery takes aim at malaria and neglected diseases . 13 February 2019 . C&EN . ACS . 2019.
  3. News: Lowe . D . The Open Source Malaria Project, So Far . 13 February 2019 . In The Pipeline .
  4. Williamson . AE . Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles . ACS Central Science . 2016 . 2 . 10 . 687–701 . 10.1021/acscentsci.6b00086 . 27800551 . 5084075 .
  5. Robertson . MN . Open source drug discovery – A limited tutorial . Parasitology . 2014 . 141 . 1 . 148–157 . 10.1017/S0031182013001121 . 23985301 . 3884843 .
  6. Tse . EG . Korsik . M . Todd . MH . The past, present and future of anti-malarial medicines . Malaria Journal . 2019 . 18 . 1 . 93 . 10.1186/s12936-019-2724-z . 30902052 . 6431062 . free .
  7. Lim . W . Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma . PLOS Neglected Tropical Diseases . 2018 . 12 . 2 . e0006437 . 10.1371/journal.pntd.0006437 . 29698504 . 5940239 . free .
  8. Web site: MycetOS – DNDi . 31 December 2017 .
  9. Park . SJ . Oxidative Arylation of Isochroman . Journal of Organic Chemistry . 2002 . 77 . 2 . 949–955 . 10.1021/jo2021373 . 22142205 .
  10. Tsang . ASK . Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ . Tetrahedron Letters . 2009 . 50 . 11 . 1199–1202 . 10.1016/j.tetlet.2008.12.101 .
  11. Hashmi . ASK . Gold-Catalysis: Reactions of Organogold Compounds with Electrophiles . Australian Journal of Chemistry . 2010 . 63 . 12 . 1619–1626 . 10.1071/CH10342 .
  12. Ahamed . M . Catalytic Asymmetric Additions of Carbon-Centered Nucleophiles to Nitrogen-Containing Aromatic Heterocycles . European Journal of Organic Chemistry . 2010 . 2010 . 31 . 5935–5942 . 10.1002/ejoc.201000877 .
  13. Todd . MH . Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids . Tetrahedron Letters . 1997 . 38 . 38 . 6781–6784 . 10.1016/S0040-4039(97)01552-9 .
  14. Todd . MH . Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry . Journal of Combinatorial Chemistry . 2001 . 3 . 3 . 319–327 . 10.1021/cc000112m . 11350256 .
  15. Todd . MH . A novel safety-catch linker for the solid-phase synthesis of amides and esters . Organic Letters . 1999 . 1 . 8 . 1149–1151 . 10.1021/ol990785h .
  16. Web site: Past Members - The Abell Group . 12 February 2019.
  17. Todd . MH . Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals . Journal of Organic Chemistry . 2002 . 67 . 12 . 3985–3988 . 10.1021/jo010990m . 12054930 .
  18. Web site: Paul A. Bartlett Group Alumni . 12 February 2019.
  19. News: Timmerman . L . A Timeline of the Turing Pharma Controversy . 12 February 2019 . Forbes.
  20. News: Reiner . V . Students make $750 drug cheaply with Open Source Malaria team . 13 February 2019 . University of Sydney . 30 November 2016.
  21. News: Davey . M . Australian students recreate Martin Shkreli price-hike drug in school lab . 12 February 2019 . The Guardian.
  22. News: Hunjan . R . Daraprim drug's key ingredient recreated by high school students in Sydney for just $20 . 12 February 2019 . ABC.
  23. News: Dunlop . G . Martin Shkreli: Australian boys recreate life-saving drug . 12 February 2019 . BBC.
  24. News: Roberts . E . 'Pharma Bro' Martin Shkreli meets his match in a group of Australian schoolboys . 12 February 2019 . CNN.
  25. Watch Martin Shkreli Respond to the School Kids Who Recreated His Drug for $2 a Dose . Lui . K . Time.
  26. Woelfle . M . Open science is a research accelerator . Nature Chemistry . 2011 . 3 . 10 . 745–748 . 10.1038/nchem.1149 . 21941234 . 2011NatCh...3..745W . 205289283 . free .
  27. Laursen . L . Tropical disease: A neglected cause . Nature . 2016 . 533 . 7602 . S68–S69 . 10.1038/533S68a . 27167396 . 2016Natur.533S..68L . free .
  28. Anderson . T . Can open-source drug development deliver? . The Lancet . 2016 . 387 . 10032 . 1983–1984 . 10.1016/S0140-6736(16)30518-9 . 27203757 . 44792421 .
  29. News: Todd . MH . Why open source pharma is the path to both new and cheaper medicines . The Guardian . 12 February 2019.
  30. Web site: Todd . MH . Open Source Drug Discovery for Malaria . 12 February 2019.
  31. News: Pearce . R . Researchers look to open source to tackle deadly infection . 12 February 2019.
  32. Web site: Open Source Research – OpenWetWare . 12 February 2019.
  33. News: Williamson . AE . Open science: the future of research? . 12 February 2019 . ABC.
  34. Web site: Chemistry Central Journal (Editorial Board) . 12 February 2019 . Chemistry Central Journal.
  35. Web site: Editorial Advisory Board . ChemistryOpen . 12 February 2019.
  36. Web site: Editorial Board . PLOS ONE . 12 February 2019.
  37. Web site: Editorial Advisory Panel and Editorial Board . Scientific Reports . 12 February 2019.
  38. Web site: Editors, Advisory Panel & Editorial Board . Scientific Data . 12 February 2019.
  39. Web site: Honour Roll – NSW Chief Scientist & Engineer . NSW Chief Scientist & Engineer . 15 October 2021 . 14 August 2020 . https://web.archive.org/web/20200814204702/https://www.chiefscientist.nsw.gov.au/premiersprizes/previous-winners . dead .
  40. Web site: ANNOUNCING THE RECIPIENTS FOR THE ACCELERATING SCIENCE AWARD PROGRAM . The Official PLOS Blog. 21 October 2013 .
  41. Web site: Blue Obelisk Awards . blueobelisk.github.io . 27 April 2019 .
  42. Web site: The Power List 2017 . The Medicine Maker. 9 August 2023 .
  43. Web site: The Power List 2018 . The Medicine Maker . 9 August 2023 .
  44. Web site: The Power List 2019 . The Medicine Maker . 9 August 2023 .
  45. Web site: The Power List 2020 . The Medicine Maker . 9 August 2023 .
  46. Web site: The Power List 2021 . The Medicine Maker . 9 August 2023 .

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