Matthew Appleyard (c. 1660 – June 1700) was an English politician.
He was the third son of Sir Matthew Appleyard (c.1607 - 1670) and his wife Frances, daughter of Sir William Pelham. He was educated at Beverley School and at St John's College, Cambridge.
He was a Member of Parliament (MP) for Hedon from 1689 to 1695.