| Matt Santangelo | |
| Height Ft: | 6 |
| Height In: | 1 |
| Weight Lb: | 176 |
| Nationality: | American / Italian |
| Birth Date: | 8 September 1977 |
| Birth Place: | Portland, Oregon |
| Highschool: | Central Catholic (Portland, Oregon) |
| College: | Gonzaga (1996–2000) |
| Draft Year: | 2000 |
| Career Start: | 2000 |
| Career End: | 2006 |
| Career Position: | Point guard |
| Years1: | 2000 |
| Team1: | Iraklis Thessaloniki |
| Years2: | 2000–2001 |
| Team2: | Pallacanestro Cantù |
| Years3: | 2001–2002 |
| Team3: | WTK Anwil Włocławek |
| Years4: | 2002–2005 |
| Team4: | Caja San Fernando |
| Years5: | 2005–2006 |
| Team5: | AMG Sebastiani Basket Rieti |
| Years6: | 2006 |
| Team6: | Benetton Treviso |
| Highlights: |
|
Matthew William Santangelo (born September 8, 1977) is an American–Italian former professional basketball player. He played college basketball at Gonzaga University.
With the USA men's basketball team he won a gold medal at the 1999 World University Games in Palma de Mallorca, Spain.