Matrix metalloproteinase inhibitor explained

A matrix metalloproteinase inhibitor (INN stem ^[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.

Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.^[2] Examples include:

• Batimastat
• Cipemastat
• Ilomastat
• Marimastat
• Prinomastat
• Tanomastat

Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.^[3]

See also

• Drug discovery and development of MMP inhibitors

References

1. Web site: The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances. World Health Organization. 5 November 2016.
2. Coussens . L. M. . Lisa Coussens . 2002 . Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations . Science . 295 . 5564 . 2387–2392 . 2002Sci...295.2387C . 10.1126/science.1067100 . 0036-8075 . 11923519 . 19944201.
3. Biochemistry Research International . Metalloproteinase Inhibitors Stts and Scope from Marine Organisms. 2010. Noel Vinay Thomas . Se Kwon Kim . 3004377. 21197102. 10.1155/2010/845975. 2010. 845975. free.