Matrilin-2 Explained

Matrilin-2 is a matrilin protein that in humans is encoded by the MATN2 gene.^{[1] [2] [3]}

This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Further reading

• Muratoglu S, Krysan K, Balázs M, etal . Primary structure of human matrilin-2, chromosome location of the MATN2 gene and conservation of an AT-AC intron in matrilin genes. . Cytogenet. Cell Genet. . 90 . 3–4 . 323–7 . 2001 . 11124542 . 10.1159/000056797 . 25764416 .
• Frank S, Schulthess T, Landwehr R, etal . Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. . J. Biol. Chem. . 277 . 21 . 19071–9 . 2002 . 11896063 . 10.1074/jbc.M202146200 . free .
• Piecha D, Hartmann K, Kobbe B, etal . Expression of matrilin-2 in human skin. . J. Invest. Dermatol. . 119 . 1 . 38–43 . 2002 . 12164922 . 10.1046/j.1523-1747.2002.01789.x . free .
• Piecha D, Wiberg C, Mörgelin M, etal . Matrilin-2 interacts with itself and with other extracellular matrix proteins. . Biochem. J. . 367 . Pt 3 . 715–21 . 2002 . 12180907 . 10.1042/BJ20021069 . 1222949 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Sharma MK, Watson MA, Lyman M, etal . Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma. . Neurology . 66 . 1 . 127–30 . 2006 . 16401863 . 10.1212/01.wnl.0000188667.66646.1c . 45662351 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .

Notes and References

1. Deak F, Piecha D, Bachrati C, Paulsson M, Kiss I . Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily . J Biol Chem . 272 . 14 . 9268–74 . May 1997 . 9083061 . 10.1074/jbc.272.14.9268 . free .
2. Mates L, Korpos E, Deak F, Liu Z, Beier DR, Aszodi A, Kiss I . Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices . Matrix Biol. . 21 . 2 . 163–74 . Mar 2002 . 11852232 . 10.1016/S0945-053X(01)00194-9 .
3. Web site: Entrez Gene: MATN2 matrilin 2.