| Mathias Caserio | |
| Fullname: | Mathias Juan Jesus Caserio |
| Birth Date: | 18 December 1986 |
| Birth Place: | Rosario, Argentina |
| Height: | 1.78 m |
| Currentclub: | Cobreloa |
| Clubnumber: | 11 |
| Position: | Midfielder |
| Years1: | 2006–2009 |
| Years2: | 2009–present |
| Clubs2: | Cobreloa |
| Caps1: | 35 |
| Caps2: | 6 |
| Goals1: | 4 |
| Goals2: | 0 |
| Pcupdate: | 00:46, 4 February 2010 (UTC) |
Mathias Juan Jesus Caserio (born December 18, 1986) is an Argentine footballer who currently plays in Chilean club Cobreloa of Calama.
Caserio began his playing career with Central Córdoba in 2006 where he won a number of championships with the team.
Since 2009 Caserio has been playing in Chile with Cobreloa.