| Massac-Séran | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Massac-Séran (Tarn).svg |
| Arrondissement: | Castres |
| Canton: | Lavaur Cocagne |
| Insee: | 81159 |
| Postal Code: | 81500 |
| Mayor: | Viviane Bonhomme[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 43.6631°N 1.8611°W |
| Elevation M: | 220 |
| Elevation Min M: | 147 |
| Elevation Max M: | 274 |
| Area Km2: | 8.52 |
Massac-Séran (in French pronounced as /masak seʁɑ̃/; Occitan (post 1500);: Maçac) is a commune in the Tarn department in southern France.