Martin Landray Explained

Honorific Prefix:Sir
Martin Landray
Alma Mater:Abingdon School
University of Birmingham
Workplaces:University of Oxford

Sir Martin Jonathan Landray (born) is a British physician, epidemiologist and data scientist who serves as a Professor of Medicine & Epidemiology at the University of Oxford. Landray designs, conducts and analyses large-scale randomised control trials; including practice-changing international trials that have recruited over 100,000 individuals.[1] Landray previously led the health informatics team that enabled the collection and management of data for the UK Biobank on over half a million people.[2]

Early life and education

Landray was born the son of a general practitioner, Bob Landray and an anaesthetist, Margaret Bray.[3] He was educated at Abingdon School in Abingdon-on-Thames, Oxfordshire, from 1982 until 1987. He was a prefect and played rugby and cricket.[4] [5] After Abingdon he went on to study medicine at the University of Birmingham, returning later for specialist training in Clinical Pharmacology & Therapeutics, and General Internal Medicine.[6]

Career

Landray serves as co-chief investigator of the RECOVERY Trial into treatment drugs for COVID-19 (the largest such clinical trial in the world) alongside Peter Horby.[7] [8] [9] In June 2020, the trial discovered the first known life-saving COVID-19 drug, Dexamethasone.[10] [11] [12] The trial also showed that Tocilizumab further reduces the risk of death for the sickest patients with COVID-19.[13] The trial found that a number of other treatments had no meaningful benefits for patients hospitalised with COVID-19, including Hydroxychloroquine,[14] Lopinavir/ritonavir,[15] Azithromycin,[16] Convalescent plasma,[17] and Colchicine.[18] The trial continues to study REGN-COV2 and Baricitinib.[19]

He leads the Good Clinical Trials Collaborative, established by Wellcome Trust, Bill & Melinda Gates Foundation, and African Academy of Sciences which seeks to develop and promote the adoption of new international guidelines for randomised control trials. He was previously one of the leaders of the Clinical Trial Transformation Initiative's[20] risk-based monitoring,[21] quality-by-design,[22] and mobile clinical trial projects.[23] He is an advocate of streamlined approaches to clinical trial design, delivery and regulation as a means to improve healthcare.[24] [25] He is founding director and chair of NHS DigiTrials,[26] the Health Data Research Hub for Clinical Trials hosted by NHS Digital, and leads the clinical trials theme for Health Data Research UK.[27]

In 2021, Landray was appointed to the Pandemic Preparedness Partnership (PPP), a group chaired by Patrick Vallance to advise the G7 presidency held by the government of Prime Minister Boris Johnson.[28]

He was knighted in the 2021 Birthday Honours for services to public health and science.

Positions held

Landray holds the following positions:[29]

See also

External links

Notes and References

  1. Web site: Why the UK is ahead of the curve in the global race to find coronavirus treatments - Q&A with Martin Landray . Reaction . 22 April 2020.
  2. News: The challenge of saving lives with 'big data' . 16 October 2020 . BBC News . 7 February 2016.
  3. Web site: The Landry Family . Bampton Archives . 14 June 2021.
  4. Web site: Prefects. The Abingdonian. 14 June 2021.
  5. Web site: Music report. The Abingdonian. 14 June 2021.
  6. Web site: Martin Landray. Nuffield Department of Population Health. 14 June 2021.
  7. Web site: ISRCTN - ISRCTN50189673: A randomised trial of treatments to prevent death in patients hospitalised with COVID-19 (coronavirus). 2020-09-06. www.isrctn.com. en.
  8. Web site: Large-scale trial for coronavirus drugs launches in UK . Clinical Trials Arena . 7 September 2020 . 6 April 2020.
  9. Web site: Managing clinical trials during the pandemic — Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences . www.ndorms.ox.ac.uk . 7 September 2020.
  10. Web site: Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 University of Oxford. 2020-09-06. www.ox.ac.uk.
  11. Web site: Prime Minister's statement on coronavirus (COVID-19): 16 June 2020. 2020-09-06. GOV.UK. 16 June 2020 . en.
  12. Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ . 6 . Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report . The New England Journal of Medicine . July 2020 . 384 . 8 . 693–704 . 32678530 . 7383595 . 10.1056/NEJMoa2021436 .
  13. RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . 2021. 33933206. RECOVERY Collaborative Group. Lancet. 397. 10285. 1637–1645. 10.1016/S0140-6736(21)00676-0 . 0140-6736 . 8084355.
  14. Group . The RECOVERY Collaborative . Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 . New England Journal of Medicine . 8 October 2020 . 383 . 21 . 2030–2040 . 10.1056/NEJMoa2022926 . 33031652 . 7556338 . en.
  15. Horby . Peter W. . Mafham . Marion . Bell . Jennifer L. . Linsell . Louise . Staplin . Natalie . Emberson . Jonathan . Palfreeman . Adrian . Raw . Jason . Elmahi . Einas . Prudon . Benjamin . Green . Christopher . Carley . Simon . Chadwick . David . Davies . Matthew . Wise . Matthew P. . Baillie . J. Kenneth . Chappell . Lucy C. . Faust . Saul N. . Jaki . Thomas . Jefferey . Katie . Lim . Wei Shen . Montgomery . Alan . Rowan . Kathryn . Juszczak . Edmund . Haynes . Richard . Landray . Martin J. . Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . The Lancet . 5 October 2020 . 396 . 10259 . 1345–1352 . 10.1016/S0140-6736(20)32013-4 . 33031764 . 7535623 . English . 0140-6736.
  16. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . 2021. 33545096. RECOVERY Collaborative Group. Lancet. 397. 10274. 605–612. 10.1016/S0140-6736(21)00149-5. 7884931.
  17. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial . 2021. 10.1016/S0140-6736(21)00897-7. Horby. Peter W.. Estcourt. Lise. Peto. Leon. Emberson. Jonathan R.. Staplin. Natalie. Spata. Enti. Pessoa-Amorim. Guilherme. Campbell. Mark. Roddick. Alistair. Brunskill. Nigel E.. George. Tina. Zehnder. Daniel. Tiberi. Simon. Aung. Ni Ni. Uriel. Alison. Widdrington. John. Koshy. George. Brown. Thomas. Scott. Steven. Baillie. J Kenneth. Buch. Maya H.. Chappell. Lucy C.. Day. Jeremy N.. Faust. Saul N.. Jaki. Thomas. Jeffery. Katie. Juszczak. Edmund. Lim. Wei Shen. Montgomery. Alan. Mumford. Andrew. Lancet. 397. 10289. 2049–2059. 34000257. 8121538. 1. 10044/1/90411. 232168245. free.
  18. Web site: RECOVERY trial closes recruitment to colchicine treatment for patients hospitalised with COVID-19 — RECOVERY Trial.
  19. Web site: Welcome — RECOVERY Trial . www.recoverytrial.net . 16 October 2020.
  20. Web site: Home . ctti-clinicaltrials.org.
  21. Web site: Archived copy . 2021-05-03 . 2021-05-03 . https://web.archive.org/web/20210503154411/https://www.ctti-clinicaltrials.org/sites/www.ctti-clinicaltrials.org/files/recommendations/monitoring-recommendations.pdf . dead .
  22. Web site: Quality by Design Clinical Trials Transformation Initiative . www.ctti-clinicaltrials.org . dead . https://web.archive.org/web/20170327092841/https://www.ctti-clinicaltrials.org/projects/quality-design . 2017-03-27.
  23. News: Entis . Laura . Can smartphone drug trials improve medical care? . 16 October 2020 . The Guardian . 27 January 2016.
  24. Improving public health by improving clinical trial guidelines and their application . 2017. 28329235. Landray. M. J.. Bax. J. J.. Alliot. L.. Buyse. M.. Cohen. A.. Collins. R.. Hindricks. G.. James. S. K.. Lane. S.. Maggioni. A. P.. Meeker-o'Connell. A.. Olsson. G.. Pocock. S. J.. Rawlins. M.. Sellors. J.. Shinagawa. K.. Sipido. K. R.. Smeeth. L.. Stephens. R.. Stewart. M. W.. Stough. W. G.. Sweeney. F.. Van De Werf. F.. Woods. K.. Casadei. B.. European Heart Journal. 38. 21. 1632–1637. 10.1093/eurheartj/ehx086. 5837481.
  25. The Magic of Randomization versus the Myth of Real-World Evidence . 2020. 32053307. Collins. R.. Bowman. L.. Landray. M.. Peto. R.. The New England Journal of Medicine. 382. 7. 674–678. 10.1056/NEJMsb1901642. 211100475.
  26. Web site: NHS DigiTrials.
  27. Web site: Clinical Trials.
  28. https://www.gov.uk/government/news/new-global-partnership-launched-to-fight-future-pandemics New global partnership launched to fight future pandemics
  29. Web site: Martin Landray — Nuffield Department of Population Health . www.ndph.ox.ac.uk . 16 October 2020.
  30. Web site: Home . ndph.ox.ac.uk.
  31. Web site: Home . bdi.ox.ac.uk.
  32. Web site: Big Data and Computing Innovation — Medical Research Council Population Health Research Unit (MRC PHRU).
  33. Web site: Clinical Informatics and Big Data.

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