Martin Kreitman Explained

Martin Kreitman
Workplaces:	University of Chicago Harvard University Stony Brook University University of Florida
Alma Mater:	Harvard University (PhD) University of Florida Stony Brook University (undergraduate)
Thesis Title:	Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster
Thesis Url:	http://search.proquest.com/docview/303271509
Thesis Year:	1983
Doctoral Advisor:	Richard Lewontin^[1] ^[2]
Known For:	McDonald–Kreitman test
Awards:	MacArthur Fellows Program (1991)

Martin Edward Kreitman is an American geneticist at the University of Chicago,^{[3] [4]} most well known for the McDonald–Kreitman test that is used to infer the amount of adaptive evolution in population genetic studies.

Education

Kreitman graduated from Stony Brook University with a Bachelor of Science degree Biology in 1975, and from the University of Florida with a Master of Science degree in Zoology, in 1977. He went on to study at Harvard University, graduating with a Ph.D. in Population Genetics, specifically Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster^[5] in 1983.^[6]

Research

The Kreitman lab does research in four main areas:^{[7] [8] [9] [10]}

Awards and honors

• 1991 MacArthur Fellows Program
• editor-in-chief of "Journal of Molecular Evolution" from 1999
• Section head of the "Evolutionary/Comparative Genetics" part of Faculty of 1000 biology ^[11]
• 2010 named fellow of the American Academy of Arts and Sciences^[12]

Recent publications

• Ludwig . M. Z. . Manu . Kittler . R. . White . K. P. . Kreitman . M. . Malik . Harmit S . 10.1371/journal.pgen.1002364 . Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness . PLOS Genetics . 7 . 11 . e1002364 . 2011 . 22102826. 3213169 . free .
• He . B. Z. . Holloway . A. K. . Maerkl . S. J. . Kreitman . M. . Petrov . Dmitri A . Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules . 10.1371/journal.pgen.1002053 . PLOS Genetics . 7 . 4 . e1002053 . 2011 . 21572512. 3084208 . free .
• Lott . S. E. . Ludwig . M. Z. . Kreitman . M. . 10.1111/j.1558-5646.2010.01206.x . Evolution and Inheritance of Early Embryonic Patterning in Drosophila Simulans and D. Sechellia . Evolution . 65 . 5 . 1388–1399 . 2011 . 21121913 . 3083464 .
• Bakker . E. G. . Traw . M. B. . Toomajian . C. . Kreitman . M. . Bergelson . J. . Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana . 10.1534/genetics.107.083279 . Genetics . 178 . 4 . 2031–2043 . 2008 . 18245336 . 2323794 .
• Araki . H. . Innan . H. . Kreitman . M. . Bergelson . J. . Molecular Evolution of Pathogenicity-Island Genes in Pseudomonas viridiflava . 10.1534/genetics.107.077925 . Genetics . 177 . 2 . 1031–1041 . 2007 . 17720907. 2034611 .
• Lott . S. E. . Kreitman . M. . Palsson . A. . Alekseeva . E. . Ludwig . M. Z. . Canalization of segmentation and its evolution in Drosophila . 10.1073/pnas.0701359104 . Proceedings of the National Academy of Sciences . 104 . 26 . 10926–10931 . 2007 . 17569783 . 1891814 . 2007PNAS..10410926L . free .
• Bakker . E. G. . A Genome-Wide Survey of R Gene Polymorphisms in Arabidopsis . 10.1105/tpc.106.042614 . The Plant Cell Online . 18 . 8 . 1803–1818 . 2006 . 16798885. 1533970.
• Bakker . E. G. . Stahl . E. A. . Toomajian . C. . Nordborg . M. . Kreitman . M. . Bergelson . J. . 10.1111/j.1365-294X.2006.02884.x . Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range . Molecular Ecology . 15 . 5 . 1405–1418 . 2006 . 16626462 . 2006MolEc..15.1405B . 2070755 .
• Araki . H. . Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis . 10.1073/pnas.0601431103 . Proceedings of the National Academy of Sciences . 103 . 15 . 5887–5892. 2006 . 16581904. 1458668. 2006PNAS..103.5887A . free .
• Nordborg . M. . Hu . T. T. . Ishino . Y. . Jhaveri . J. . Toomajian . C. . Zheng . H. . Bakker . E. . Calabrese . P. . Gladstone . J. . Goyal . 10.1371/journal.pbio.0030196 . R. . Jakobsson . M. . Kim . S. . Morozov . Y. . Padhukasahasram . B. . Plagnol . V. . Rosenberg . N. A. . Shah . C. . Wall . J. D. . Wang . J. . Zhao . K. . Kalbfleisch . T. . Schulz . V. . Kreitman . M. . Bergelson . J. . The Pattern of Polymorphism in Arabidopsis thaliana . PLOS Biology . 3 . 7 . e196 . 2005 . 15907155. 1135296 . free .
• Ludwig . M. Z. . Palsson . A. . Alekseeva . E. . Bergman . C. M. . Nathan . J. . Kreitman . M. . 10.1371/journal.pbio.0030093 . Functional Evolution of a cis-Regulatory Module . PLOS Biology . 3 . 4 . e93 . 2005 . 15757364. 1064851 . free .
• Kreitman . M. . Di Rienzo . A. . 10.1016/j.tig.2004.05.002 . Balancing claims for balancing selection . Trends in Genetics . 20 . 7 . 300–304 . 2004 . 15219394 .
• Goss . E. M. . Kreitman . M. . Bergelson . J. . 10.1534/genetics.104.031351 . Genetic Diversity, Recombination and Cryptic Clades in Pseudomonas viridiflava Infecting Natural Populations of Arabidopsis thaliana . Genetics . 169 . 1 . 21–35 . 2004 . 15489535 . 1448860 .
• Mauricio . R. . Stahl . E. A. . Korves . T. . Tian . D. . Kreitman . M. . Bergelson . J. . Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana . Genetics . 163 . 2 . 735–746 . 2003 . 10.1093/genetics/163.2.735 . 12618410 . 1462445.
• Tian . D. . Traw . M. B. . Chen . J. Q. . Kreitman . M. . Bergelson . J. . Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana . 10.1038/nature01588 . Nature . 423 . 6935 . 74–77 . 2003 . 12721627 . 2003Natur.423...74T . 4394776 .
• Toomajian . C. . Ajioka . R. S. . Jorde . L. B. . Kushner . J. P. . Kreitman . M. . A method for detecting recent selection in the human genome from allele age estimates . Genetics . 165 . 1 . 287–297 . 2003 . 10.1093/genetics/165.1.287 . 14504236 . 1462736.
• Tian . D. . Signature of balancing selection in Arabidopsis . 10.1073/pnas.172203599 . Proceedings of the National Academy of Sciences . 99 . 17 . 11525–11530 . 2002 . 12172007. 123289. 2002PNAS...9911525T . free .
• Toomajian . C. . Kreitman . M. . Sequence variation and haplotype structure at the human HFE locus . Genetics . 161 . 4 . 1609–1623 . 2002 . 10.1093/genetics/161.4.1609 . 12196404 . 1462210.
• Jakob . K. . Goss . E. M. . Araki . H. . Van . T. . Kreitman . M. . Bergelson . J. . 10.1094/MPMI.2002.15.12.1195 . Pseudomonas viridiflavaandP. Syringae—Natural Pathogens ofArabidopsis thaliana . Molecular Plant-Microbe Interactions . 15 . 12 . 1195–1203 . 2002 . 12481991 .
• Comeron . J. M. . Kreitman . M. . Population, evolutionary and genomic consequences of interference selection . Genetics . 161 . 1 . 389–410 . 2002 . 10.1093/genetics/161.1.389 . 12019253 . 1462104.
• Nordborg . M. . Borevitz . J. O. . Bergelson . J. . Berry . C. C. . Chory . J. . Hagenblad . J. . Kreitman . M. . Maloof . J. N. . Noyes . T. . Oefner . 10.1038/ng813 . P. J. . Stahl . E. A. . Weigel . D. . The extent of linkage disequilibrium in Arabidopsis thaliana . Nature Genetics . 30 . 2 . 190–193 . 2002 . 11780140 . 29420110 .
• Bergman . C. M. . Kreitman . M. . Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences . 10.1101/gr.178701 . Genome Research . 11 . 8 . 1335–1345 . 2001 . 11483574 . free .
• Bergelson . J. . Kreitman . M. . Stahl . E. A. . Tian . D. . Evolutionary Dynamics of Plant R-Genes . 10.1126/science.1061337 . Science . 292 . 5525 . 2281–2285 . 2001 . 11423651. 21638017 .
• Comeron . J. M. . Kreitman . M. . The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces . Genetics . 156 . 3 . 1175–1190 . 2000 . 10.1093/genetics/156.3.1175 . 11063693 . 1461334.
• Ludwig . M. Z. . Bergman . C. . Patel . N. H. . Kreitman . M. . Evidence for stabilizing selection in a eukaryotic enhancer element . 10.1038/35000615 . Nature . 403 . 6769 . 564–567 . 2000 . 10676967 . 2000Natur.403..564L . 4425113 .
• Bergelson . J. . Stahl . E. A. . Dwyer . G. . Mauricio . R. . Kreitman . M. . Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis . Nature . 400 . 6745 . 667–671 . 1999 . 10.1038/23260 . 10458161 . 1999Natur.400..667S . 4380447 .
• Comeron . J. M. . Kreitman . M. . Aguadé . M. . Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila . Genetics . 151 . 1 . 239–249 . 1999 . 10.1093/genetics/151.1.239 . 9872963 . 1460462.
• Ludwig . M. Z. . Patel . N. H. . Kreitman . M. . Functional analysis of eve stripe 2 enhancer evolution in Drosophila: Rules governing conservation and change . Development . 125 . 5 . 949–958 . 1998 . 10.1242/dev.125.5.949 . 9449677.

External links

• "Martin Kreitman", Scientific Commons

Notes and References

1. Web site: On the 30th Anniversary of DNA Sequencing in Population Genetics | I wish you'd made me angry earlier . 2013-08-24 . https://web.archive.org/web/20130824114513/http://caseybergman.wordpress.com/2013/08/04/on-the-30th-anniversary-of-dna-sequencing-in-population-genetics/ . dead .
2. Keith . T. P. . Riley . M. A. . Kreitman . M. . Martin Kreitman. Lewontin . R. C. . Richard Lewontin. Curtis . D. . Chambers . G. . Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster . Genetics . 116 . 1 . 67–73 . 1987 . 10.1093/genetics/116.1.67 . 3036646 . 1203122.
3. Web site: Bio . pondside.uchicago.edu. 2021-01-05.
4. Web site: Martin Kreitman | Recovery Act Funding | the University of Chicago.
5. PhD . Martin Edward. Kreitman . Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster . Harvard University . 1983 . Martin Kreitman. .
6. Web site: University of Chicago - Molecular Biosciences . 2010-04-25 . dead . https://web.archive.org/web/20100610080101/http://molbio.bsd.uchicago.edu/Faculty_and_Research/01_Faculty_Alphabetically.php?faculty_id=88 . 2010-06-10 .
7. Kreitman . M. . Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster . 10.1038/304412a0 . Nature . 304 . 5925 . 412–417 . 1983 . 6410283. 1983Natur.304..412K . 4348580 .
8. McDonald . J. H. . Kreitman . Martin. Martin Kreitman. 10.1038/351652a0 . Adaptive protein evolution at the Adh locus in Drosophila . Nature . 351 . 6328 . 652–654 . 1991 . 1904993. 1991Natur.351..652M . 205024070 .
9. Hudson . R. R. . Kreitman . M. . Aguadé . M. . A test of neutral molecular evolution based on nucleotide data . Genetics . 116 . 1 . 153–159 . 1987 . 10.1093/genetics/116.1.153 . 3110004 . 1203113.
10. Kreitman . Martin. Martin Kreitman. 10.1146/annurev.genom.1.1.539 . Methods to detect selection In populations with applications to the human . Annual Review of Genomics and Human Genetics . 1 . 539–559 . 2000 . 11701640. free .
11. Web site: Faculty of 1000 | About . www.f1000biology.com . 20 July 2022 . https://web.archive.org/web/20040708171633/http://www.f1000biology.com/about/members/8008 . 8 July 2004 . dead.
12. Web site: IGSB senior fellow Martin Kreitman named fellow of the American Academy of Arts and Sciences « News & Events « Institute for Genomics and Systems Biology . www.igsb.org . 20 July 2022 . https://web.archive.org/web/20100911233529/http://www.igsb.org/news/martin-kreitman-named-fellow-of-the-american-academy-of-arts-and-sciences/ . 11 September 2010 . dead.