Marnie Blewitt Explained

Marnie E. Blewitt
Birth Name:	Marnie E. Blewitt
Nationality:	Australian
Education:	University of Sydney (University Medalist)
Alma Mater:	University of Sydney (PhD, 2005)
Field:	Epigenetics
Work Institutions:	Walter and Eliza Hall Institute, University of Melbourne
Doctoral Advisor:	Emma Whitelaw
Known For:	X-inactivation
Prizes:	Genetics Society of Australia DG Catcheside L'Oréal-UNESCO Awards for Women in Science

Marnie Blewitt is head of a division at WEHI, which focuses on X-inactivation, and is engaged in research on the role of polycomb-group proteins in hematopoietic stem cell function.

Scientific career

Education

She completed undergraduate studies in 1999 at The University of Sydney,^[1] with honours and a double major of Molecular Biology and Genetics.^[2] As part of her doctoral research at the same institution under the supervision of Associate Professor Emma Whitelaw, she designed a sensitised mutagenesis screen to find new epigenetic modifiers in mice, for which she was awarded the Genetics Society of Australia DG Catcheside prize for the best PhD in genetics. She moved to Melbourne at the end of 2005 to accept a Peter Doherty post-doctoral fellowship in Doug Hilton's^[3] lab from 2005 to 2009, before becoming laboratory head in January 2010.^[4]

Research interests

Blewitt's lab focuses on molecular mechanisms behind epigenetic control of gene expression. Her lab has worked on one of the mouse mutants identified in the mutagenesis screen, identifying a critical role for the protein Smchd1 in X inactivation in cancer.^[5] Other research activities include the study of the roles of polycomb-group proteins in hematopoietic stem cell function.

Teaching and public service

Marnie Blewitt conducted a massive open online course in epigenetics at Coursera starting on 28 April 2014.^[6]

Awards and honors

• Genetics Society of Australia D.G. Catcheside Prize (2006)^[7]
• National Health and Medical Research Council Fellowship (2006)
• L'Oréal-UNESCO Awards for Women in Science (2009)^[8]
• National Health and Medical Research Council Grants (2008, 2011, 2012, 2013)
• Australian Academy of Science Ruth Stephens Gani Medal (2009)^[9]

Personal life

Blewitt is married and has two children.

Selected publications

• Blewitt ME, Gendrel A-V, Pang Z, Sparrow DB, Whitelaw N, Craig J, Apedaile A, Hilton DJ, Dunwoodie SL, Brockdorff N, Kay GK and Whitelaw E (2008) SmcHD1, a protein containing a structural maintenance of chromosomes hinge domain, has a critical role in X inactivation. Nat Genet May; 40(5):663-9.
• Majewski IJ, Blewitt M, deGraaf C, McManus E, Bahlo M, Hyland C, Smyth GK, Corbin J, Metcalf D, Alexander WS, and Hilton DJ (2008) Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell identity. PLoS Biology 15 Apr; 6(4):e93.
• Blewitt ME, Vickaryous NK, Hemley SJ, Ashe A, Bruxner TJ, Preis JI, Arkell R and Whitelaw E (2005) An ENU screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21): 7629–7634.
• Ashe A, Morgan DK, Whitelaw NC, Bruxner TJ, Vickaryous NK, Cox LL, Butterfield NC, Wicking C, Blewitt ME, Wilkins S, Anderson G, Cox TX and Whitelaw E. (2008) A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol Vol 9 (12) R182
• Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, Hemley S, Stopka T, Skoultchi A, Matthews J, Scott H, de Kretser D, O’Bryan M, Blewitt M and Whitelaw E (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 2007 May;39(5):614-22. Epub 2007 Apr 22.
• Blewitt ME, Vickaryous NK, Paldi A Koseki H and Whitelaw E (2006) Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genetics April 2(4) e49.
• Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KVK and Whitelaw E (2003) Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs following maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5): 2538–43

External links

• Marnie Blewitt Faculty page, Walter and Eliza Hall Institute

Notes and References

1. Web site: Graduate profile – Marnie Blewitt.
2. Web site: Dr Marnie E Blewitt.
3. Web site: Marnie Blewitt.
4. Web site: Dr. Marnie Blewitt.
5. Web site: Dr Marnie Blewitt.
6. Web site: Dr. Marnie Blewitt.
7. Web site: Linkage. April 2007.
8. Web site: Reading the Genome. dead. https://web.archive.org/web/20140517134113/http://www.scienceinpublic.com.au/loreal/fellows/reading-the-genome. 17 May 2014. dmy-all.
9. Web site: RUTH STEPHENS GANI MEDAL. 7 May 2009. 23 May 2014. https://archive.today/20140523232258/http://www.sciencearchive.org.au/events/sats/sats2009/ecr_awards_blewitt.html. 23 May 2014. dead.