| Mark Twain School | |
| Coordinates: | 36.7661°N -90.4011°W |
| Architect: | Walker, L.B.; Litton, J.W. |
| Architecture: | Classical Revival |
| Added: | February 5, 1998 |
| Area: | less than one acre |
| Mpsub: | Poplar Bluff MPS |
| Refnum: | 98000031 |
Mark Twain School, also known as the Poplar Bluff Museum, is a historic school building located at Poplar Bluff, Butler County, Missouri. It was built in 1910, and is a two-story, "H"-plan, Classical Revival style brick building. The building consists of two, parallel, rectangular-plan, hipped roof blocks joined by an enclosed two-story flat roof corridor. It remained in use as an elementary school until 1988.[1]
It was listed on the National Register of Historic Places in 1998.