| Mark Twain Hotel | |
| Coordinates: | 39.7092°N -91.3547°W |
| Built: | , 1918 |
| Architect: | Barnett, Haynes & Barnett |
| Architecture: | Renaissance |
| Added: | August 1, 1986 |
| Mpsub: | Hannibal Central Business District MRA |
| Refnum: | 86002136 |
Mark Twain Hotel is a historic hotel building located at Hannibal, Marion County, Missouri. It was designed by Barnett, Haynes & Barnett and built in 1905. It is a four-story, Renaissance Revival style steel-frame structure with a granite foundation and beige pressed-brick exterior. The annex was built in 1918. It features semicircular arches over the main door and adjacent windows.[1]
It was then added to the National Register of Historic Places in 1986.