Mark Soloway Explained

Mark Soloway
Birth Date:1943
Birth Place:Midwest
Education:
Occupation:Surgeon
Profession:Urologist
Work Institutions:
Specialism:Prostate, bladder and kidney cancer
Prizes:

Mark S. Soloway (born 1943) is an American emeritus professor of urology, known for his work on prostate, bladder and kidney cancer. From 1991 to 2010 he was professor and chairman of the University of Miami Miller School of Medicine (MSM) Department of Urology, and subsequently chief of urologic oncology at Memorial Hospital in Hollywood, Florida.

After graduating in medicine from Case Western Reserve University School of Medicine, Soloway began a two-year clinical fellowship at the National Cancer Institute (NCI) of the National Institute of Health (NIH) in Bethesda, Maryland. There, he developed an animal model to investigate the efficacy of several investigational chemotherapeutic drugs for the treatment of bladder cancer, and tested the hypothesis that the high rate of local recurrence of urothelial tumors may be the result of implantation of tumor cells on the urothelial surface following endoscopic resection of bladder tumors. He subsequently returned to Case Western Reserve to complete his residency in urology.

Early life and education

Mark Soloway was born in the Midwest in 1943.[1] [2] In 1964 he received a bachelor's degree in biology from Northwestern University in Chicago.[3] Subsequently he studied medicine at the Case Western Reserve University School of Medicine in Cleveland, from where he graduated in 1968.[3] [4] Whilst there, he was inspired towards translational research by neurosurgeon Robert J. White.[2]

Early career

In 1968 Soloway began a two-year clinical fellowship at the National Cancer Institute (NCI) of the National Institute of Health (NIH) in Bethesda, Maryland, where his contributions to the field of urology began.[2] [4] There, he developed an animal model for bladder cancer for the purpose of finding a better treatment for locally advanced or spreading bladder cancer.[4] [5] [6] This FANFT-induced bladder cancer in mice allowed him to investigate the effectiveness of several investigational chemotherapy drugs for bladder cancer.[7] [8] At the same time he also tested the hypothesis that the high rate of local recurrence of urothelial tumors may be the result of implantation of tumor cells on the urothelial surface following endoscopic resection of bladder tumors.[2] [9] By developing an orthotopic bladder implantation animal tumor model, Soloway was able to establish that an injury to the urothelium created the necessary environment for tumor implantation and the scientific evidence in support of early intravesical chemotherapy following transurethral resection of a bladder tumor.[10] [11] This included his research with cisplatin, then known as cis-diamminedichloro platinum .[12] [13] [14] After completing his fellowship Soloway returned to Case Western Reserve to complete his residency in urology.[2] [4] He then joined the University of Tennessee.[15] His research also included some early studies on combining cisplatin with radiation.[16] [17]

Later career

From 1991 to 2010 Soloway was professor and chairman of the University of Miami Miller School of Medicine (MSM) Department of Urology.[4] In 2014 he became chief of urologic oncology at Memorial Hospital in Hollywood, Florida.[18]

Soloway was one of the first urologic oncologists to use flexible cystoscopy as an integral part of his office practice; today, the majority of the world uses it.[19]

Transrectal Ultrasonography for Prostate Cancer

Soloway's work in bladder cancer was largely initiated by laboratory work using his animal model and his research on prostate cancer has been more clinically oriented and has focused in six different areas: the use of transrectal ultrasonography for the diagnosis of prostate cancer; the development of the periprostatic nerve block to decrease pain during biopsy; the evaluation of the role of androgen deprivation prior to radical prostatectomy for locally advanced prostate cancer; the importance of quality of life in treatment decision-making; the recognition of active surveillance as a management strategy for low-risk prostate cancer; and surgical techniques for total prostatectomy.

Soloway promoted the TRUS biopsy method to urologists for their outpatient clinics.[20] [21] [22] In an effort to minimize the discomfort from biopsies, he also popularized the use of the periprostatic nerve block.[23] [24] This procedure is used to minimize the pain associated with a prostate biopsy and is used in over 500,000 procedures annually in the US alone.

Evaluating Androgen Deprivation

During the 1980s and early 1990s, a high percentage of men with prostate cancer were diagnosed with locally advanced disease. Anecdotally, many of them were given the then newly developed LHRH analogs as initial treatment for their disease. Since their initial responses were impressive, it seemed reasonable to give androgen deprivation prior to prostatectomy with the hope of improving progression free and overall survival.[25] [26] Enlisting the cooperation of a multi-institutional group, Soloway initiated a prospective randomized trial to test the efficacy of neoadjuvant androgen deprivation therapy. This randomized trial showed that although the surgical margin rate was lower for men who had received androgen deprivation prior to prostatectomy, there was no improvement in progression free or overall survival.[27] [26]

Positive Surgical Margins

Another focus of Soloway's clinical research has been on the relationship between positive surgical margins and the preservation of the bladder neck and approach to the seminal vesicles. His first publication in 1996 on this topic detailed pathological analysis of the location and consequences of positive surgical margins.[28] In a more recent paper published in the Journal of Urology, he reported that the recurrence rate was only 20% in his patient cohort with a positive surgical margin and therefore, the routine adjuvant radiation therapy would over treat 80% of the patients.[29] [30] On the subject of urinary continence, for over 20 years, Soloway has been a proponent of bladder neck preservation for enhancing urinary continence without compromising cancer control for patients undergoing radical prostatectomy.[31] [32] Soloway and M. Manoharan have worked together to minimize the side effects of a radical prostatectomy. They have popularized the lower abdominal transverse incision to minimize pain and enhance recovery as well as providing a smaller, less obvious scar.[33] They have shown that most patients do not require a drain[34] [35] [36] and an inguinal hernia can be easily be repaired at the same operation of a radical prostatectomy using this transverse incision.[37] [38]

Watchful Waiting Approach

With the advent of PSA and early detection of prostate cancer, Soloway, concerned about the risk of overtreatment, has been an advocate of active surveillance for patients with low-risk, low volume Gleason 6 prostate cancer who are compliant with careful monitoring. In 2000 he published his first series of patients including those eligible for watchful waiting, as well as active surveillance and reported that only a few of these patients went on to have treatment.[39] Using a tighter definition for active surveillance, Soloway's group reported that less than 15% of these prostate cancer patients went on to treatment.[40] This series was updated recently in European Urology with the addition of quality of life parameters and a constant of 15% progressing to treatment.

Work on Renal Tumors

Over the last two decades, Soloway has worked closely in tandem with a former resident and co-faculty member, Gaetano Ciancio on kidney cancer. Together they have revolutionized the surgical approach for large renal tumors, particularly those in which the tumor extends into the vena cava. Ciancio is a urologist, who is fellowship trained in renal and liver transplantation. More than 10 years ago, Soloway and Ciancio worked as a team to reduce the perioperative morbidity and mortality associated with these large tumor masses. Their idea was to incorporate surgical techniques from liver transplantation to increase the exposure of the vena cava with the anticipation that this would reduce blood loss and obviate circulatory arrest. Together they have published over 35 articles beginning with their first description of this technique in 2000.[41] Their most recent publication[42] is an update of their step-by-step approach toward minimizing complications related to renal cell carcinoma with vena cava thrombus. This series emphasizes the improvements in safety and reduction in operative mortality and morbidity related to their technique. Since most tertiary medical centers where these procedures are likely to be performed now have liver transplant surgeons, this technique can easily be duplicated.

Cancer Support Group

Soloway developed one of the first prostate cancer support groups in Memphis, Tennessee. In 1992, he co-authored one of the first QOL studies[43] examining patient preference related to LHRH versus orchiectomy for patients with advanced disease. In 1995 Soloway and his colleagues reported on a study that looked at patients with localized prostate cancer and the QOL implications of surgical management vs. radiation therapy.[44] Recognizing that prostate cancer is a couple's disease, Soloway also studied the psychosocial and sexual implications of this disease on patients and their partners.[45]

Awards and honors

Soloway's awards include the American Urological Association's Gold Cystoscope Award in 1984 and the Presidential Citation of 2008.[46] Others include the Mosby Scholarship for Scholastic Excellence award (1967), and North Central Section of American Urological Association Traveling Fellowship award (1972).[47] Soloway was honored with a corresponding membership in the German Urology Association and the Dutch Urologic Society.[48] Soloway has been the visiting professor in over 50 academic programs both nationally and internationally and a guest speaker at national meetings in over 30 countries.[49] [50] [51] He was one of the founding members of the International Urologic Research Society. In 2004–2005 Soloway served the chair of the first International Panel on Cancer,[52] a project that included fourteen individual panels and over one hundred experts in different aspects of bladder cancer. The Societe Internationale de Urologie (the governing body of the International Panel on Bladder Cancer)[53] and the International Consultation of Urologic Diseases have jointly commissioned him again to chair the second International Panel on Bladder Cancer.[54] In 2015 the British Association of Urological Surgeons awarded him the St Paul's Medal.[55]

Selected publications

Further reading

Notes and References

  1. Web site: Mark Soloway — OfficialUSA.com Records . www.officialusa.com . 5 August 2024. https://web.archive.org/web/20240808130414/https://www.officialusa.com/names/Mark-Soloway/. 8 August 2024.
  2. Legends in urology . Canadian Journal of Urology . February 2009 . 16 . 1 . 4447–4449 . 19222879 . https://web.archive.org/web/20240702102419/https://www.canjurol.com/html/free-articles/V16I01-2-Legends_Feb09.pdf. 2 July 2024.
  3. Web site: Mark Soloway . https://web.archive.org/web/20240809134436/https://health.usnews.com/doctors/mark-soloway-20878 . 9 August 2024 . 5 August 2024 . health.usnews.com.
  4. Web site: Emeritus Member: Mark Soloway, MD, FACS . Bladder Cancer Advocacy Network . 31 July 2024. https://web.archive.org/web/20240731162446/https://bcan.org/staff/mark-soloway-md-facs/. 31 July 2024.
  5. Lee . Jin Seok . Bae . Min Ho . Choi . Sung Ho . Lee . Sang Hun . Cho . Young Sam . Park . Heung Jae . Kwon . Chil Hun . Joo . Kwan Joong . Tumor Establishment Features of Orthotopic Murine Bladder Cancer Models . Korean Journal of Urology . June 2012 . 53 . 6 . 396–400 . 10.4111/kju.2012.53.6.396 . 22741047 . 3382688 . 2005-6737.
  6. Book: Cancer Treatment Reports . 1983 . U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health . 572 . en.
  7. Seo . Ho Kyung . Shin . Seung-Phil . Jung . Na-Rae . Kwon . Whi-An . Jeong . Kyung-Chae . Lee . Sang-Jin . The establishment of a growth-controllable orthotopic bladder cancer model through the down-regulation of c-myc expression . Oncotarget . 22 July 2016 . 8 . 31 . 50500–50509 . 10.18632/oncotarget.10784 . 28881578 . 5584157 . en . 1949-2553.
  8. Web site: EAU 2020: Five Things I Wish I Would Have Known Earlier in My Career: Lessons from the Mentors - Bladder Cancer . www.urotoday.com . 5 August 2024.
  9. Sweeney . Sean K . Luo . Yi . O’Donnell . Michael A . Assouline . Jose . Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles . Cancer Nanotechnology . 2016 . 7 . 3 . 10.1186/s12645-016-0015-8 . free . 27217840 . 4846680 . 1868-6958.
  10. Book: Droller . Michael J. . Urothelial Tumors . 2004 . PMPH-USA . 978-1-55009-173-1 . 34 . en.
  11. Book: Zingg . E. J. . Wallace . D. M. A. . Bladder Cancer . 2012 . Springer . 978-1-4471-1362-1 . 30–33 . en.
  12. Book: Dirix . L. Y. . Oosterom . A. T. van . Banzet . P. . Holland . J. F. . Khayat . D. . Weil . M. . Cancer Treatment An Update . 1994 . Springer . 978-2-8178-0767-6 . 58 . https://books.google.com/books?id=e2sFCAAAQBAJ&pg=PA58. en . Systemic treatment of bladder cancer.
  13. Book: Spiers . A. S. D. . Chemotherapy and Urological Malignancy . 6 December 2012 . Springer Science & Business Media . 978-1-4471-1332-4 . 375 . en.
  14. Funt . Samuel A. . Rosenberg . Jonathan E. . Systemic, perioperative management of muscle-invasive bladder cancer and future horizons . Nature Reviews. Clinical Oncology . April 2017 . 14 . 4 . 221–234 . 10.1038/nrclinonc.2016.188 . 27874062 . 6054138 . 1759-4774.
  15. Web site: Soloway Mark - Faculty - 7th International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer . https://web.archive.org/web/20240805141242/https://www.erasmus.gr/microsites/1017/soloway-mark . 5 August 2024 . www.erasmus.gr . en.
  16. Book: Rotman . Marvin . Rosenthal . C. Julian . Rotman . Marvin . Rosenthal . C. Julian . Concomitant Continuous Infusion Chemotherapy and Radiation . 1991 . Springer . Berlin . 978-3-642-84186-6 . 5 . https://books.google.com/books?id=GazrCAAAQBAJ&pg=PA5 . en . The development of chemotherapy drugs as radiosensitizers: an overview.
  17. Book: Dutta . Pink R. . Whittington . Richard . Hanno . Philip M. . Wein . Alan J. . Malkowicz . S. Bruce . Penn Clinical Manual of Urology . 2007 . Elsevier . Philadelphia . 978-1-4160-3848-1 . 633 . https://books.google.com/books?id=L4aaBOGZ3hEC&pg=PA633 . en . 17. Radiation therapy.
  18. Web site: Mark Soloway MD Chief of Urologic Oncology Memorial Cancer Institute Awarded International Medal . mhs.net . 9 August 2024.
  19. Nieder AM, Soloway MS. Cystoscopy In. Lerner SP, Schoenberg MP, Sternberg CN. Textbook of Bladder Cancer, 2006. Taylor and Francis, England. pgs 179–185.
  20. Hardeman SW, Wake, R.W., and Soloway MS. The role of prostate specific antigen and transrectal ultrasound in the diagnosis and management of prostate cancer. Postgraduate Medicine, 86:197-208, 1989.
  21. Hardeman SW, Wake RW, Soloway MS. Two new techniques for evaluating prostate cancer. The role of prostate-specific antigen and transrectal ultrasound. Postgrad Med, 86(2):197–198, 201, 204 passim, 1989.
  22. Hardeman SW, Causey JQ, Hickey DP, Soloway MS. Transrectal ultrasound for staging prior to radical prostatectomy. Urology, 34(4):175–180, 1989.
  23. Soloway MS, Obek C. Periprostatic local anesthesia before ultrasound guided prostate biopsy. J Urol, 163(1):172–173, 2000.
  24. Alavi AS, Soloway MS, Vaidya A, Lynne CM, Gheiler EL. Local anesthesia for ultrasound guided prostate biopsy: a prospective randomized trial comparing 2 methods. J Urol, 166(4):1343–1345, 2001.
  25. MS . Soloway . R . Sharifi . Z . Wajsman . D . McLeod . DP . Wood . A . Puras-Baez . Randomized prospective study comparing radical prostatectomy alone versus radical prostatectomy preceded by androgen blockade in clinical stage B2 (T2bNxM0) prostate cancer. The Lupron Depot Neoadjuvant Prostate Cancer Study Group . The Journal of Urology . 1995 . J Urol . 154 . 2 Pt 1 . 424–428 . 10.1016/S0022-5347(01)67067-8 . 0022-5347 . 7541859 .
  26. Soloway MS, Pareek K, Sharifi R, Wajsman Z, McLeod D, Wood DP, Jr., Puras-Baez A. Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results. J Urol, 167(1):112–116, 2002.
  27. Soloway MS, Sharifi R, Wajsman Z, McLeod D, Wood DP, Jr., Puras-Baez A. Randomized prospective study comparing radical prostatectomy alone versus radical prostatectomy preceded by androgen blockade in clinical stage B2 (T2bNxM0) prostate cancer. The Lupron Depot Neoadjuvant Prostate Cancer Study Group. J Urol, 154(2 Pt 1):424–428, 1995.
  28. Watson RB, Civantos F, Soloway MS. Positive surgical margins with radical prostatectomy: detailed pathological analysis and prognosis. Urology, 48(1):80-90, 1996.
  29. Wieder JA, Soloway MS. Incidence, etiology, location, prevention and treatment of positive surgical margins after radical prostatectomy for prostate cancer. J Urol, 160(2):299-315, 1998.
  30. Simon MA, Kim S, Soloway MS. Prostate specific antigen recurrence rates are low after radical retropubic prostatectomy and positive margins. J Urol, 175(1):140–144, 2006.
  31. Shelfo SW, Obek C, Soloway MS. Update on bladder neck preservation during radical retropubic prostatectomy: impact on pathologic outcome, anastomotic strictures, and continence. Urology, 51(1):73-78, 1998.
  32. Soloway MS, Neulander E. Bladder-neck preservation during radical retropubic prostatectomy. Semin Urol Oncol, 18(1):51-56, 2000.
  33. Manoharan M, Gomez P, Sved P, Soloway MS. Modified Pfannenstiel approach for radical retropubic prostatectomy. Urology, 64(2):369-371, 2004.
  34. Savoie M, Soloway MS, Kim SS, Manoharan M. A pelvic drain may be avoided after radical retropubic prostatectomy. J Urol, 170(1):112–114, 2003.
  35. Araki M, Manoharan M, Vyas S, Nieder AM, Soloway MS. A pelvic drain can often be avoided after radical retropubic prostatectomy--an update in 552 cases. Eur Urol, 50(6):1241–1247, 2006.
  36. Sachedina N, De Los Santos R, Manoharan M, Soloway MS. Total prostatectomy and lymph node dissection may be done safely without pelvic drainage: an extended experience of over 600 cases. Can J Urol, 16(4):4721–4725, 2009.
  37. Manoharan M, Gomez P, Soloway MS. Concurrent radical retropubic prostatectomy and inguinal hernia repair through a modified Pfannenstiel incision. BJU Int, 93(9):1203–1206, 2004.
  38. Manoharan . Murugesan . Vyas . Sachin . Araki . Motoo . Nieder . Alan M. . Soloway . Mark S. . 30 May 2006 . Concurrent radical retropubic prostatectomy and Lichtenstein inguinal hernia repair through a single modified Pfannenstiel incision: a 3-year experience . BJU International . Wiley . 98 . 2 . 341–344 . 10.1111/j.1464-410x.2006.06270.x . 16879675 . 1464-4096.
  39. Neulander EZ, Duncan RC, Tiguert R, Posey JT, Soloway MS. Deferred treatment of localized prostate cancer in the elderly: the impact of the age and stage at the time of diagnosis on the treatment decision. BJU Int, 85(6):699–704, 2000.
  40. Soloway MS, Soloway CT, Williams S, Ayyathurai R, Kava B, Manoharan M. Active surveillance; a reasonable management alternative for patients with prostate cancer: the Miami experience. BJU Int, 101(2):165–169, 2008.
  41. Ciancio G, Hawke C, Soloway MS. The use of liver transplant techniques to aid in the surgical management of urological tumors. J Urol,164(3 Pt 1):665–672, 2000.
  42. Ciancio G, Gonzalez J, Shirodkar SP, Angulo JC, Soloway MS: Liver transplantation techniques for the surgical management of renal cell carcinoma with tumor thrombus in the inferior vena cava: Step-by-step description. Eur Urol (in print).
  43. Cassileth BR, Soloway MS, Vogelzang NJ, Chou JM, Schellhammer PD, Seidmon EJ, Kennealey GT. Quality of life and psychosocial status in stage D prostate cancer. Zoladex Prostate Cancer Study Group. Qual Life Res, 1(5):323–329, 1992.
  44. Braslis KG, Santa-Cruz C, Brickman AL, Soloway MS. Quality of life 12 months after radical prostatectomy. Br J Urol, 75(1):48–53, 1995.
  45. Soloway . Cynthia T. . Soloway . Mark S. . Kim . Sandy S. . Kava . Bruce R. . March 24, 2005 . Sexual, psychological and dyadic qualities of the prostate cancer 'couple' . . . 95 . 6 . 780–785 . 10.1111/j.1464-410x.2005.05400.x . 15794782 . 1464-4096.
  46. Web site: AUA Award History New York Section, AUA . https://web.archive.org/web/20240808063854/https://nyaua.com/awards/aua-award-history . 8 August 2024 . 7 August 2024 . nyaua.com.
  47. North Central Section of the American Urological Association Awards. 2011. Accessed October 11, 2011. http://www.ncsaua.org/meetings/awards.aspx
  48. Mark Soloway Leads German Urological Association Conference. 2011. Accessed October 11, 2011. Web site: Berlin 2011 | SIU World Meeting . 2011-10-24 . dead . https://web.archive.org/web/20111029070249/http://www.siucongress.org/2011/schedule.asp . October 29, 2011 .
  49. Mark Soloway Recognized as World-Renown Urologic Oncologist. 2011. Accessed October 11, 2011. (http://www.urologysurgeon.com.au/about)
  50. Web site: SIU Scholarship: Dr. Sachit Sharma . dead . https://web.archive.org/web/20120331043552/http://www.siu-urology.org/userfiles/files/SIUScholarSharma.pdf . March 31, 2012 . 2011-10-24 . siu-urology.org . The JPAC hosted 3 international and 2 national conferences during my 6-month stay, with such distinguished international faculty as Dr. Inderbir Gill, Dr. Mihir Desai, Professor Mark Soloway..
  51. BCAN (Bladder Cancer Advocacy Network) Describes Dr. Soloway’s Achievements. 2011. Accessed October 11, 2011. Web site: Mark Soloway, M.D., FACS at Bladder Cancer Advocacy Network – BCAN . 2011-10-24 . dead . https://web.archive.org/web/20120425091159/http://www.bcan.org/about/advisory-board/dr-mark-soloway-md-facs . April 25, 2012 .
  52. Mark Soloway Leads International Panel on Urologic Cancer. 2011. Accessed October 11, 2011. Web site: Research | Sylvester . 2011-10-24 . dead . https://web.archive.org/web/20101128184331/http://sylvester.org/research/research-knowledgebase/scientist?name=m_soloway . November 28, 2010 .
  53. Mark Soloway Speaks at the Societe Internationale de Urologie Conference. 2011. Accessed October 11, 2011. Web site: Archived copy . 2011-10-24 . dead . https://web.archive.org/web/20120331043552/http://www.siu-urology.org/userfiles/files/SIUScholarSharma.pdf . March 31, 2012 .
  54. Mark Soloway Co-Chairs the International Consultation of Bladder Cancer. 2011. Updated July 14, 2011. http://www.icud.info/futureconsultations.html
  55. Web site: St Paul's Medal Winners . www.baus.org.uk . British Association of Urological Surgeons . 9 August 2024 . en.

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