| Mario Pérez | |
| Fullname: | Mario Pérez Guadarrama |
| Birth Date: | 30 December 1946 |
| Birth Place: | Mexico City, Mexico |
| Position: | Defender |
| Years1: | 1965–1970 |
| Years2: | 1970–1978 |
| Years3: | 1978–1979 |
| Clubs1: | Necaxa |
| Clubs2: | América |
| Clubs3: | Tampico Madero |
| Caps3: | 35 |
| Goals3: | 2 |
| Nationalyears1: | 1967–1973 |
| Nationalteam1: | Mexico |
| Nationalcaps1: | 30 |
| Nationalgoals1: | 1 |
| Manageryears1: | 1986–1987 |
| Managerclubs1: | Necaxa |
| Manageryears2: | 2003–2004 |
| Managerclubs2: | Alacranes de Durango |
| Manageryears3: | 2008–2009 |
| Managerclubs3: | Pioneros de Cancún |
| Manageryears4: | 2009–2012 |
| Managerclubs4: | Guerreros de Acapulco |
| Manageryears5: | 2012 |
| Managerclubs5: | Reynosa |
| Manageryears6: | 2013 |
| Managerclubs6: | Tampico Madero |
| Manageryears7: | 2018 |
| Managerclubs7: | Gavilanes de Matamoros |
Mario Pérez Guadarrama (born 30 December 1946[1]) is a Mexican former professional footballer who played as a defender for the Mexico national team between 1967 and 1973. He was part of the Mexico squad for the 1970 World Cup.
After he retired from playing, Pérez became a football manager. He was appointed manager of Club Necaxa in 1986.[2]