| Fullname: | Mario Humberto Lobo |
| Birth Date: | 21 August 1964 |
| Birth Place: | San Salvador de Jujuy, Jujuy Province, Argentina |
| Years1: | 1986–1987 |
| Clubs1: | Gimnasia |
| Years2: | 1987–1989 |
| Clubs2: | Independiente |
| Years3: | 1990 |
| Clubs3: | Sporting Cristal |
| Years4: | 1990–1991 |
| Clubs4: | Independiente |
| Years5: | 1992–1995 |
| Clubs5: | Gimnasia |
| Years6: | 1996 |
| Clubs6: | Santiago Wanderers |
| Years7: | 1997–2000 |
| Clubs7: | Gimnasia |
| Years8: | 2000–2001 |
| Clubs8: | Chacarita Juniors |
| Years9: | 2000–2001 |
| Clubs9: | Atletico Tucuman |
| Years10: | 2002–2004 |
| Clubs10: | Gimnasia |
| Clubs11: | Altos Hornos Zapla |
| Years11: | 2005 |
Mario Humberto Lobo (born August 21, 1964, in San Salvador de Jujuy, Argentina) is an Argentine former footballer. He played for clubs in Argentina, Chile and Peru.