| Type: | Bishop |
| Honorific-Prefix: | His Excellency |
| Mario Espinoza Contreras | |
| Native Name Lang: | Spanish |
| Bishop of Mazatlán | |
| Church: | Catholic Church |
| Diocese: | Roman Catholic Diocese of Mazatlán |
| Appointed: | 2 April 1996 |
| Term: | 2005-present |
| Term Start: | 3 March 2005 |
| Predecessor: | Rafael Barraza Sánchez |
| Ordination: | 14 July 1973 |
| Consecration: | 11 May 1996 |
| Consecrated By: | Adolfo Antonio Suárez Rivera |
| Birth Date: | 22 November 1949 |
| Birth Place: | Tepic, Nayarit |
| Nationality: |  Mexico |
| Coat Of Arms: | Coat of arms of Vatican City State - 2023 version.svg |
| Coat Of Arms Alt: | Vatican's coat of arms |
Mario Espinosa Contreras (22 November 1949) is a Roman Catholic bishop who serves as Bishop of the Roman Catholic Diocese of Mazatlán in Mexico since 2005.
Born on November 22, 1949, in Tepic, Nayarit, Mexico, Mario Espinosa Contreras became a priest in his hometown and later bishop in Tehuacán and Mazatlán,[1] In 2024, he spoke about the kidnapping of 66 people in Culiacán during the Palm Sunday mass from the altar of the Basilica Cathedral of Mazatlán.[2]