| Mario Ardissone | |
| Birth Date: | 1900 10, df=yes |
| Birth Place: | Vercelli, Italy |
| Death Date: | 1975 |
| Position: | Midfielder |
| Years1: | 1919–1935 |
| Clubs1: | Pro Vercelli |
| Caps1: | 355 |
| Goals1: | 75 |
| Nationalyears1: | 1924 |
| Nationalteam1: | Italy |
| Nationalcaps1: | 2 |
| Nationalgoals1: | 0 |
Mario Ardissone (pronounced as /it/; 9 October 1900 – 1975) was an Italian footballer who played as a midfielder.
Ardissone played for 6 seasons (161 games, 6 goals) in the Italian Serie A for U.S. Pro Vercelli Calcio. Ardissone made his debut for the Italy national football team on 20 January 1924 in a game against Austria. He was also part of Italy's squad at the 1924 Summer Olympics, but he did not play.[1]