| Mario Acerbi | |
| Birth Date: | 1913 7, df=yes |
| Birth Place: | Lodi, Italy |
| Death Place: | Lodi, Italy |
| Position: | Defender |
| Years1: | 1932–1939 |
| Years2: | 1939–1943 |
| Years3: | 1945–1947 |
| Years4: | 1947–1948 |
| Clubs3: | Fanfulla |
| Clubs4: | Olubra |
| Caps2: | 77 |
| Goals2: | 0 |
Mario Acerbi (1 July 1913 – 20 February 2010) was an Italian professional football player.
He played for four seasons (77 games, no goals) in the Serie A for A.S. Roma.