Marinobufagenin Explained

Marinobufagenin (marinobufagin) is a cardiotonic bufadienolide steroid. It can be found in the plasma and urine of human subjects with myocardial infarction, kidney failure, and heart failure.[1] It is also secreted by the toad Bufo rubescens[2] and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis.[3]

References

  1. Tian . Jiang . Renal ischemia regulates marinobufagenin release in humans . Hypertension . 7 September 2010 . 56 . 5 . 914–919 . 10.1161/hypertensionaha.110.155564 . 20823380 . 2959137 .
  2. 15804527 . 2005 . Cunha Filho . GA . Schwartz . CA . Resck . IS . Murta . MM . Lemos . SS . Castro . MS . Kyaw . C . Pires Jr . OR . Leite . JR . Bloch . Carlos . Schwartz . Elisabeth Ferroni . Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens . 45 . 6 . 777–82 . 10.1016/j.toxicon.2005.01.017 . Toxicon. 8 .
  3. 11877366 . 2002 . Fedorova . OV . Talan . MI . Agalakova . NI . Lakatta . EG . Bagrov . AY . Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension . 105 . 9 . 1122–7 . Circulation . 10.1161/hc0902.104710. free .

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