Marilyn Kozak Explained

Marilyn S. Kozak
Birth Place:Akron, Ohio, US
Birth Date:1943 7, mf=yes
Fields:Microbiology
Workplaces:Robert Wood Johnson Medical School
Alma Mater:Johns Hopkins University
Doctoral Advisor:Daniel Nathans
Academic Advisors:Aaron Shatkin
Known For:Kozak consensus sequence

Marilyn S. Kozak is an American professor of biochemistry at the Robert Wood Johnson Medical School. She was previously at the University of Medicine and Dentistry of New Jersey before the school was merged. She was awarded a PhD in microbiology by Johns Hopkins University studying the synthesis of the Bacteriophage MS2, advised by Daniel Nathans.[1] [2] In her original faculty job proposal, she sought to study the mechanism of eukaryotic translation initiation, a problem long thought to have already been solved by Joan Steitz. [3] While in the Department of Biological Sciences at University of Pittsburgh, she published a series of studies that established the scanning model of translation initiation and the Kozak consensus sequence.[4] [5] [6] Her current research interests are unknown as her last publication was in 2008.[7]

Recognition

Marilyn Kozak was listed as one of the top 10 Women Scientists of the 80's in an article published by The Scientist. This was awarded based on the number of citations for their published work between 1981-1988. During this time, Kozak had 3,107 citations. Her most cited work was from 1984, entitled "Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs".[8] This paper highlighted the research that brought the known cellular mRNAs from 32 to 166.

Controversy

In March 2001, Kozak published a mini-review in the Journal of Molecular and Cellular Biology entitled "New Ways of Initiating Translation in Eukaryotes?" that resulted in push-back from the scientific community.[9] In her publication, Kozak discussed her hesitation towards the role of cellular internal ribosome entry sites (IRES). This was most heavily refuted by Robert Schneider, who published a response article of the same name in the same Journal in Dec. 2001.[10] In this response, Schneider claimed that in publishing her mini-review, Kozak hoped to increase the validity of her own findings. He further stated that Kozak's publication was not up to scholarly standards and should not have been accepted into the Journal of Molecular and Cellular Biology. The existence of cellular IRESes remains controversial.[11] [12] [13]

Contributions

Along with her published work, Kozak has contributed to the scientific community with her role on the editorial board for the Journal of Molecular and Cellular Biology. She has been listed intermittently as an editor between the years 1983-1991.[14] [15] [16]

Selected works

This is a selection of Kozak's work but not a complete list.

Notes and References

  1. Kozak. M. Nathans. D. Translation of the genome of a ribonucleic acid bacteriophage.. Bacteriological Reviews. March 1972. 36. 1. 109–34. 4555183. 378432. 10.1128/MMBR.36.1.109-134.1972.
  2. Kozak. M. Nathans. D. Differential inhibition of coliphage MS2 protein synthesis by ribosome-directed antibiotics.. Journal of Molecular Biology. 14 September 1972. 70. 1. 41–55. 4561347. 10.1016/0022-2836(72)90162-3.
  3. Kozak. Marilyn. Identifying AUG Initiator Codons. Citation Classic Commentaries. 4 October 1993. 36. 40. 4 July 2015.
  4. News: Grissom. Abigail. Research: Top 10 Women Scientists Of The '80s: Making A Difference. 4 July 2015. The Scientist. 15 October 1990.
  5. Kozak. M. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.. Nucleic Acids Research. 26 October 1987. 15. 20. 8125–48. 3313277. 10.1093/nar/15.20.8125. 306349.
  6. Kozak. M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.. Cell. 31 January 1986. 44. 2. 283–92. 3943125. 10.1016/0092-8674(86)90762-2. 15613863.
  7. Kozak. Marilyn. 2008-11-01. Faulty old ideas about translational regulation paved the way for current confusion about how microRNAs function. Gene. 423. 2. 108–115. 10.1016/j.gene.2008.07.013. 18692553. 0378-1119.
  8. Kozak. Marilyn. 1984-01-25. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Research. 12. 2. 857–872. 10.1093/nar/12.2.857. 6694911. 318541. 0305-1048.
  9. Kozak. Marilyn. 2001-03-15. New Ways of Initiating Translation in Eukaryotes?. Molecular and Cellular Biology. 21. 6. 1899–1907. 10.1128/MCB.21.6.1899-1907.2001. 0270-7306. 11238926. 86772.
  10. Schneider. Robert. 2001. New Ways of Initiating Translation in Eukaryotes?. Molecular and Cellular Biology. 21. 23. 8238–8246. 10.1128/MCB.21.23.8238-8246.2001. 0270-7306. 11710333. 99989.
  11. Bert . Andrew . Assessing IRES activity in the HIF-1alpha and other cellular 5' UTRs . RNA . 2006 . 12 . 6 . 1074–1083 . 10.1261/rna.2320506 . 16601206 . 1464860 .
  12. Jackson . Richard . The Current Status of Vertebrate Cellular mRNA IRESs . Cold Spring Harbor Perspectives in Biology . 2013 . 5 . 2 . a011569. 10.1101/cshperspect.a011569 . 23378589 . 3552511.
  13. Yang . Yun . TIRES-mediated cap-independent translation, a path leading to hidden proteome . Journal of Molecular Cell Biology . 2019 . 11 . 10 . 911–919 . 10.1093/jmcb/mjz091 . 31504667 . 6884710.
  14. Molecular and Cellular Biology Editorial Board. 1983. Journal of Molecular and Cellular Biology. 368623.
  15. Web site: Molecular and Cellular Biology Editorial Board. 1988. Journal of Molecular and Cellular Biology.
  16. Web site: Molecular and Cellular Biology Editorial Board. 1991. Journal of Molecular and Cellular Biology.
  17. Kozak. M.. 1991-11-15. An analysis of vertebrate mRNA sequences: intimations of translational control.. The Journal of Cell Biology. 115. 4. 887–903. 10.1083/jcb.115.4.887. 0021-9525. 1955461. 2289952.
  18. Kozak. M.. 1986-05-01. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proceedings of the National Academy of Sciences. 83. 9. 2850–2854. 10.1073/pnas.83.9.2850. 0027-8424. 3458245. 323404. 1986PNAS...83.2850K. free.
  19. Kozak. Marilyn. 1987-08-20. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. Journal of Molecular Biology. 196. 4. 947–950. 10.1016/0022-2836(87)90418-9. 3681984. 0022-2836.
  20. Kozak. Marilyn. January 1986. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell. 44. 2. 283–292. 10.1016/0092-8674(86)90762-2. 0092-8674. 3943125. 15613863.
  21. Kozak. Marilyn. 1981-10-24. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Research. 9. 20. 5233–5252. 10.1093/nar/9.20.5233. 7301588. 327517. 0305-1048.

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