| Mariepauá River | |
| Pushpin Map: | Brazil |
| Mouth Location: | Madeira River, Novo Aripuanã, Amazonas |
| Mouth Coordinates: | -5.265°N -60.5557°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Mariepauá River (pt|Rio Mariepauá) is a tributary of the Madeira River in the state of Amazonas, Brazil.
The river defines the western boundary of the Juma Sustainable Development Reserve, created in 2006 to support sustainable extraction of forest resources by the traditional population.Two new species of fish have been found in the river.In March 2015 Google launched imagery of the river in its "Street View" feature of Google Maps.