| Marie | |
| Reign: | 1250–1260 |
| Spouse: | Alphonso of Brienne |
| Issue: | John I |
| Father: | Raoul II of Lusignan |
| House: | House of Lusignan |
| Mother: | Yolande de Dreux |
| Death Date: | 1 October 1260 |
| Death Place: | Poitou |
Marie of Lusignan or Marie I de Lusignan (died in Poitou, 1 October 1260; buried at the Abbey of Foucarmont), was the only child of Raoul II of Lusignan and his second wife, Yolande de Dreux. She became Dame d'Exoudun, Countess of Eu on the death of her father in 1246.
She was married around 1249 to Alphonso of Brienne who became Count of Eu by this marriage.
Marie and Alphonso had at least two children: