| Consort: | yes |
| Marie of Brandenburg-Kulmbach | |
| Succession: | Electress Palatine |
| Reign: | 12 February 1559 – 31 October 1567 |
| Spouse: | Frederick III, Elector Palatine |
| Issue: | Alberta Louis VI, Elector Palatine Elizabeth Hermann Louis Johann Casimir of Simmern Dorothea Susanne, Duchess of Saxe-Weimar Albert Anne Elizabeth Christopher Charles Cunigunde, Countess of Nassau-Dillenburg |
| House: | House of Hohenzollern |
| Father: | Casimir, Margrave of Brandenburg-Bayreuth |
| Mother: | Susanna of Bavaria |
| Birth Date: | 14 October 1519 |
| Birth Place: | Ansbach |
| Death Date: | 31 October 1567(aged 48) |
| Death Place: | Heidelberg |
| Burial Place: | Church of the Holy Spirit, Heidelberg |
Marie of Brandenburg-Kulmbach (14 October 1519 – 31 October 1567) was a Princess of Brandenburg-Kulmbach and by marriage Electress Palatine.
Marie was the oldest child of the Margrave Casimir of Brandenburg-Kulmbach (1481–1527) from his marriage with Susanna of Bavaria (1502–1543), daughter of Duke Albert IV of Bavaria. After her father's death Marie was raised in the Lutheran faith by her uncle George Frederick.
On 21 October 1537, in Kreuznach, Marie married Frederick of Simmern (b. 1515), later Elector Palatine (1559–1576). The marriage was happy. Marie, who is described as intelligent and religious, influenced her Catholic husband toward Protestantism. In 1546, Frederick finally adopted Lutheranism and assumed the administration of the Franconian territories from his brother-in-law Albert Alcibiades, Margrave of Brandenburg-Kulmbach. Since their family was living in reduced circumstances, Marie repeatedly turned to her uncle Albert of Prussia for financial assistance.
After the death of Marie's stepfather Otto-Henry in 1559, her consort Frederick became Elector Palatine. As Electress, she was closely involved in governmental affairs, though Frederick tolerated no direct interference. She had influence in religious questions, and as a strong Lutheran she was a determined opponent of the Zwinglians.
The Electress spent the last year of her life suffering from gout and was mostly confined to her bed.
She was buried in the Church of the Holy Spirit in Heidelberg.
By her marriage, Marie had the following children:
m. (1) 1560 Princess Elizabeth of Hesse (1539–1582)
m. (2) 1583 Princess Anne of Ostfriesland (1562–1621)
m. 1558 Duke John Frederick II of Saxony (1529–1595)
m. 1570 Princess Elizabeth of Saxony (1552–1590)
m. 1560 Duke John William I of Saxe-Weimar (1530–1573)
m. (1) 1569 Landgrave Philip II of Hesse-Rheinfels (1541–1583)
m. (2) 1599 Count Palatine John Augustus of Veldenz-Lützelstein (1575–1611)
m. 1580 Count John VI of Nassau-Dillenburg (1536–1606)
| Marie of Brandenburg-Kulmbach | Father: Casimir, Margrave of Brandenburg-Bayreuth | Paternal Grandfather: Frederick I, Margrave of Brandenburg-Ansbach | Paternal Great-grandfather: Albrecht III, Elector of Brandenburg |
| Paternal Great-grandmother: Anna of Saxony | |||
| Paternal Grandmother: Sophia of Poland | Paternal Great-grandfather: Casimir IV Jagiellon | ||
| Paternal Great-grandmother: Elisabeth of Austria | |||
| Mother: Susanna of Bavaria | Maternal Grandfather: Albert IV, Duke of Bavaria | Maternal Great-grandfather: Albert III, Duke of Bavaria | |
| Maternal Great-grandmother: Anna of Brunswick-Grubenhagen-Einbeck | |||
| Maternal Grandmother: Kunigunde of Austria | Maternal Great-grandfather: Frederick III, Holy Roman Emperor | ||
| Maternal Great-grandmother: Eleanor of Portugal |
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