| Mariano Ruíz-Esquide | |
| Birth Date: | 1936 4, df=y |
| Birth Place: | Talcahuano, Chile |
| Death Date: | 2024 1, df=y |
| Death Place: | Vina del Mar, Chile |
| Office: | Member of the Senate of Chile |
| Constituency: | Bío Bío Region (19th Circumscription) |
| Term Start: | 11 March 1990 |
| Term End: | 11 March 2014 |
| Predecessor: | Creation of the Circumscription |
| Successor: | Felipe Harboe |
| Office1: | Member of the Chamber of Deputies of Chile |
| Constituency1: | Bío Bío Region (17th Departamental Agrupation) |
| Term Start1: | 15 May 1965 |
| Term End1: | 11 September 1973 |
| Party: | Christian Democratic Party |
| Alma Mater: | University of Chile (LL.B) |
| Occupation: | Politician |
| Profession: | Lawyer |
| Spouse: | Inés Figueroa |
| Children: | Three |
Mariano Ruiz-Esquide (10 May 1930[1] – 20 January 2024) was a Chilean surgeon and politician who served as a Senator. He died on 20 January 2024, at the age of 93.[2]