| Settlement Type: | City |
| Official Name: | Mariano Roque Alonso |
| Pushpin Map: | Paraguay |
| Flag Size: | 130px |
| Seal Size: | 100px |
| Mapsize: | 200px |
| Subdivision Type: | Country |
| Subdivision Name: | Paraguay |
| Subdivision Type1: | Department |
| Subdivision Name1: | Central Department |
| Area Total Km2: | 122 |
| Population As Of: | 2016 |
| Population Total: | 97585 |
| Population Density Km2: | 696 |
| Coordinates: | -25.2122°N -57.5331°W |
| Elevation M: | 64 |
| Area Code: | 021 |
| Blank Name: | Climate |
| Blank Info: | Am |
Mariano Roque Alonso (pronounced as /es/) is a district and city located in the Central Department, in Paraguay in the Gran Asunción metropolitan area. The city has a population of 85,000 people.
The city was founded in 1944 and is located between the Paraguay River and the Transchaco Road, some 18 kilometers away from the city of Asunción. This optimal location has allowed the city quick commercial, industrial, and social development.
The town is known because on the afternoon of February 4, 1996, LAC Colombia Flight 028 crashed while taking off from Silvio Pettirossi International Airport, killing the 4 crew and 18 people on the ground. With 22 people dead, it is the worst air accident in the history of Paraguay.
Mariano Roque Alonso is home to the site of the biggest annual Expo show in Paraguay where companies and industries showcase their latest products.