Marianne Grunberg-Manago Explained

Marianne Grunberg-Manago
Birth Date:	6 January 1921
Birth Place:	Petrograd (now St Petersburg), Soviet Union
Death Place:	Paris, France
Nationality:	French
Field:	Biochemistry

Marianne Grunberg-Manago (January 6, 1921 – January 3, 2013) was a Soviet-born French biochemist. Her work helped make possible key discoveries about the nature of the genetic code. Grunberg-Manago was the first woman to lead the International Union of Biochemistry and the 400-year-old French Academy of Sciences.

Early life

Grunberg-Manago was born into a family of artists who adhered to the teachings of the Swiss educational reformer Johann Pestalozzi. When she was 9 months old, her parents emigrated from the Soviet Union to France.

Education and Research

Grunberg-Manago studied biochemistry and, in 1955, while working in the lab of Spanish-American biochemist Severo Ochoa,^[1] she discovered the first nucleic-acid-synthesizing enzyme.^[2] Initially, everyone thought the new enzyme was an RNA polymerase used by E. coli cells to make long chains of RNA from separate nucleotides.^[3]

Although the new enzyme could link a few nucleotides together, the reaction was highly reversible and it later became clear that the enzyme, polynucleotide phosphorylase, usually catalyzes the breakdown of RNA, not its synthesis.^[4] Nonetheless, the enzyme was extraordinarily useful and important. Almost immediately, Marshall Nirenberg and J. Heinrich Matthaei put it to use to form the first three-nucleotide RNA codons, which coded for the amino acid phenylalanine. This first step in cracking the genetic code entirely depended on the availability of Grunberg-Manago’s enzyme.^[5]

In 1959, Ochoa and Arthur Kornberg won the 1959 Nobel Prize in Physiology or Medicine "for the synthesis of the nucleic acids RNA and DNA." She was elected a Foreign Honorary Member of the American Academy of Arts and Sciences in 1978,^[6] a Foreign Associate Member of the National Academy of Sciences in 1982,^[7] and an International member of the American Philosophical Society in 1992.^[8]

Grunberg-Manago was the first woman president of the International Union of Biochemistry (1985–1988), and she was also the first woman to preside over the French Academy of Sciences (1995–1996).

Later life and death

Late in her career, Grunberg-Manago was named emeritus director of research at CNRS, France's National Center for Scientific Research.

Grunberg-Manago died in January 2013, three days before her 92nd birthday.^[9]

Awards and nominations

• Member of the EMBO (1964)
• Charles-Léopold-Mayer Prize from the French Academy of Sciences (1966)
• Foreign member of the American Society of Biological Chemists (1972)
• Member of the Federation of American Societies for Experimental Biology)
• Member of the French Society for biochemistry and molecular biology
• Foreign member of the Franklin Society (1995)
• Member of the Spanish Society for molecular biology
• Member of the Greek Society for molecular biology
  • Member of the Executive Board of the ICSU Foreign member of the New York Academy of Sciences (1977)
• Foreign member of the American Academy of Arts and Sciences (1978)^[6]
• Foreign member of the National Academy of Sciences in the United States (1982)
• Honorary foreign member of the USSR Academy of Sciences (1988)
• Member of Academia Europaea (1988)
• Honorary foreign member of the Russian Academy of sciences (1991)
• Foreign member of the Ukrainian Academy of Sciences (1991)
• Grand Officer of the National Order of the Legion of Honor(2008)

Notes and References

1. Grunberg-Manago . M. . Marianne Grunberg-Manago. 10.1098/rsbm.1997.0020 . Severo Ochoa. 24 September 1905--1 November 1993: Elected For.Mem.R.S. 1965 . . 43 . 351–365. 1997 . Severo Ochoa . free .
2. Grunberg-Manago. Marianne. Ortiz, P . Ochoa, S . Enzymic synthesis of polynucleotides. I. Polynucleotide phosphorylase of Azotobacter vinelandii.. Biochimica et Biophysica Acta. April 1956. 20. 1. 269–85. 13315374. 10.1016/0006-3002(56)90286-4.
3. Grunberg-Manago . M. . Oritz . P. J. . Ochoa . S. . Enzymatic synthesis of nucleic acidlike polynucleotides . Science . 122 . 3176 . 907–910 . 1955 . 13274047 . 10.1126/science.122.3176.907. 1955Sci...122..907G .
4. Symmons. Martyn F.. Jones. George H.. Luisi. Ben F.. 2000-11-15. A Duplicated Fold Is the Structural Basis for Polynucleotide Phosphorylase Catalytic Activity, Processivity, and Regulation. Structure. 8. 11. 1215–1226. 10.1016/S0969-2126(00)00521-9. 11080643. free.
5. Grunberg-Manago . M. . Enzymatic synthesis of nucleic acids . 1963 . Progress in Biophysics and Molecular Biology . 13 . 175–239 . 10.1016/s0079-6107(63)80016-4 . 0079-6107 . 14135921. free .
6. Web site: Book of Members, 1780–2010. American Academy of Arts and Sciences.
7. Web site: Marianne Grunberg-Manago. National Academy of Sciences. July 30, 2014.
8. Web site: APS Member History . 2022-03-28 . search.amphilsoc.org.
9. "L'Académie des sciences a le regret de faire part du décès de Marianne Grunberg-Manago survenu à Paris le 3 janvier 2013." News: Le 3 janvier, décès de Marianne Grunberg-Manago . January 2013 . . fr . 9 January 2013 . dead . https://web.archive.org/web/20130220003439/http://www.academie-sciences.fr/index.htm . 20 February 2013 .