| Mariana de Aguirre | |
| Office: | First Lady of Chile |
| Term Label: | In role |
| Term Start: | 2 November 1829 |
| Term End: | 7 December 1829 |
| President: | Francisco Ramón Vicuña |
| Birth Name: | Mariana Viviana de Aguirre y Bosa |
| Birth Date: | 1775 |
| Birth Place: | Chile |
| Spouse: | Francisco Ramón Vicuña |
| Parents: | José Santos de Aguirre y Díez de Aséndegui Antonia de Bosa de Lima y Andía-Irarrázaval |
| Children: | 11 |
Mariana Viviana de Aguirre y Bosa (baptised 3 December 1775)[1] was First Lady of Chile as wife of Chile's President Francisco Ramón Vicuña (1775–1849), with whom she had six children.
She was born in Santiago, Chile to father José Santos de Aguirre y Díez de Aséndegui, 2nd Marquis of Montepío, and mother Antonia de Bosa de Lima y Andía-Irarrázaval. As born in 1775 would not she be considered a peasant or noblewoman of the Chile of the 18th Century.