Maria Ruth B. Pineda-Cortel Explained

Maria Ruth B. Pineda-Cortel
Fields:Biological sciences and medical technology
Alma Mater:University of Santo Tomas (B.S., M.S., and Ph.D.)
Known For:Gestational Diabetes mellitus, Climate change, dengue and malaria
Awards:ASEAN-US Science Prize for Women 2020 (finalist)

Dr. Maria Ruth B. Pineda-Cortel is an associate professor and laboratory coordinator at the University of Santo Tomas (UST) where she teaches at the Department of Medical Technology of the Faculty of Pharmacy.[1] [2] She also does research at the university's Research Center for the Natural Sciences and Applied Sciences (RCNAS).[3] Pineda-Cortel has done extensive research focusing on gestational diabetes mellitus (GDM, also known as diabetes during pregnancy) and polycystic ovarian syndrome (PCOS) as a way to shed light on diseases that only affect women. As a woman of science, she advocates and works towards improving healthcare for women. Pineda-Cortel has also done research covering many health-related issues that include the effects of climate change on infectious diseases that are prevalent in the Philippines, such as dengue and malaria.[4]

Education

Pineda-Cortel studied at the University of Santo Tomas in Manila, Philippines where she received all of her degrees: Bachelor of Science in Medical Technology, Master of Science in Medical Technology, and Doctor of Philosophy with a major in Biological Sciences.[5]

Career and research

Gestational Diabetes Mellitus

Pineda-Cortel focuses her research on early-detection and diagnosis of GDM in pregnant women in the Philippines. The prevalence of GDM in the Philippines is around 30%, and Pineda-Cortel aims to increase accessibility and availability of standard diagnostic and screening tests for GDM to prevent further health complications in the mother and the baby. Her goal is to find early genetic biomarkers that can be identified in pregnant women to prevent the development of GDM. She carries out her experiments by collecting blood samples every trimester from a group of pregnant women with no diabetes (non-GDM group) and another group of pregnant women that have diabetes before pregnancy and/or had GDM during past pregnancies (GDM group). The RNA from the blood samples are then analyzed through differential gene expression to compare the read counts of relevant genes between the non-GDM group and the GDM group during first, second, and third trimester.[6] In one of her studies, she concludes that the gene variant rs7754840 of the CDKAL1 gene (known to inhibit insulin production) does not increase susceptibility to GDM.[7] Another one of her studies also suggests that iron deficiency anemia in pregnant women decreases the risk of developing GDM.[8] Pineda-Cortel's research is an effort to end the cycle of transgenerational diabetes as its prevalence continues to increase all over the world.[9]

Dengue and climate change

Pineda-Cortel also does research to determine the effects of climate change and other environmental factors on dengue incidence and number of cases per region. Her studies show a strong correlation between the incidence of dengue and temperature, rainfall and humidity. Because the Philippines lie in the tropics, these three climate variables are the main driving force of dengue fever. Warmer temperatures speed up the extrinsic incubation period of the dengue virus and the development of mosquitoes which increases disease transmission rates. In addition, her research also demonstrates that rainfall contributes to an increase in dengue cases as stagnant water provides breeding grounds for mosquitoes. With these contributing factors in mind, Pineda-Cortel developed prediction models of dengue cases in four studied regions in the Philippines.[10]

Selected publications

Awards and recognition

!Year!Title!Institution!Ref.
2021Educators Excellence Award in ResearchPhilippine Association of Schools of Medical Technology[11]
2020ASEAN-U.S. Science Prize for Women National FinalistAssociation of Southeast Asian Nations[12]
2018ASEAN Science DiplomatAssociation of Southeast Asian Nations
2016Gawad Pananaliksik (Outstanding Performance in Research)University of Santo Tomas Faculty of Pharmacy
2014-2015Crisanto Almario Research Award – Most Outstanding Researcher in the field of Medical TechnologyPhilippine Association of Medical Technologists, Inc.

Notes and References

  1. Web site: Department of Medical Technology - . 2022-05-05 . en-US.
  2. Web site: 2020-05-01 . Pineda-Cortel of MedTech, RCNAS is Philippine finalist in ASEAN-US Science Prize for Women - . 2022-05-05 . en-US.
  3. Web site: Research Center for Natural and Applied Sciences - . 2022-05-05 . en-US . 2022-05-22 . https://web.archive.org/web/20220522113928/https://www.ust.edu.ph/research/research-center-for-natural-and-applied-sciences/ . dead .
  4. Web site: Dr. Maria Ruth B. Pineda-Cortel – ASEAN-US Science Prize for Women Supported by UL . 27 April 2020 . 2022-05-05 . en-US.
  5. Web site: PINEDA-CORTEL, Maria Ruth B. - . 2022-05-05 . en-US.
  6. 10.1016/j.diabres.2021.109046 . free . Differential gene expression and network-based analyses of the placental transcriptome reveal distinct potential biomarkers for gestational diabetes mellitus . 2021 . Pineda-Cortel . Maria Ruth B. . Bunag . Jose Angelo A. . Mamerto . Therriz P. . Abulencia . Miguel Francisco B. . Diabetes Research and Clinical Practice . 180 . 109046 . 34530062 . 237545700 .
  7. 10.4103/2305-0500.321123 . free . Genetic association of rs7754840 and rs7756992 polymorphisms in the CDKAL1 gene and gestational diabetes mellitus in selected Filipino pregnant women . 2021 . Villavieja . Adrian . Pineda-Cortel . Maria Ruthb. . Baybayan . Karlo . Bello . Peterlouie . Camenforte . Latiffalois . Ching . Stefanyjane . Conti . Kathleen . Ignacio . Jeremiahjose . Diaz . Jiovanni . Pandac . Jefferylkae . Alejandro . Emilynu . Asian Pacific Journal of Reproduction . 10 . 4 . 155 . 236483869 .
  8. 10.1007/s00404-018-4932-0. Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: A meta-analysis . 2019 . Tiongco . Raphael Enrique . Arceo . Engracia . Clemente . Benjie . Pineda-Cortel . Maria Ruth . Archives of Gynecology and Obstetrics . 299 . 1 . 89–95 . 30315412 . 52973732 .
  9. 10.3390/ijms21145003. free . Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes . 2020 . Alejandro . Emilyn U. . Mamerto . Therriz P. . Chung . Grace . Villavieja . Adrian . Gaus . Nawirah Lumna . Morgan . Elizabeth . Pineda-Cortel . Maria Ruth B. . International Journal of Molecular Sciences . 21 . 14 . 5003 . 32679915 . 7404253 .
  10. 10.4103/1995-7645.250838 . free . Modeling and predicting dengue fever cases in key regions of the Philippines using remote sensing data . 2019 . Pineda-Cortel . Mariaruth B. . Clemente . Benjiem . Nga . Phamthi Thanh . Asian Pacific Journal of Tropical Medicine . 12 . 2 . 60 . 92837751 .
  11. Web site: 2021-10-02 . Pineda-Cortel, Manahan of MedTech receive 2021 PASMETH Educators Awards of Excellence - . 2022-05-05 . en-US.
  12. Web site: You are being redirected... . 2022-05-05 . asean.org.

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