| Motto: | Aiming for Excellence! |
| Established: | 1957 |
| Type: | Public high school |
| Principal: | Amy Stevens-Cox |
| Grades: | 9 - 12 |
| Address: | 7710 Old Big Bend Road |
| City: | Gibsonton |
| Zipcode: | 33534 |
| Country: | U.S. |
| District: | Hillsborough County Public Schools |
| Accreditation: | Florida State Department of Education |
| Enrollment: | 1,995 (2022–2023)[1] |
| Ratio: | 22.67 |
| Staff: | 88.00 (FTE) |
| Colors: | Red and Grey |
| Nickname: | Indians |
East Bay High School is a public high school in Gibsonton, Florida. It was chartered in 1957 on Big Bend Road in Gibsonton. The school's current facility was established in 1972 on a new campus adjacent to the east of the old one. Its former campus is now the campus of Eisenhower Middle School.
East Bay HS is 34.4% Hispanic, 28.8% White, 26.9% Black, 2.6% Asian, 0.2% Native American, and 7.0% multiracial.[2]