| Maria Antonia of Naples and Sicily | |
| Princess of Asturias | |
| House: | Bourbon-Two Sicilies |
| Full Name: | Italian Maria Antonietta Teresa Amelia Giovanna Battista Francesca Gaetana Maria Anna Lucia |
| Father: | Ferdinand IV of Naples and III of Sicily |
| Mother: | Maria Carolina of Austria |
| Birth Date: | 14 December 1784 |
| Birth Place: | Caserta Palace, Caserta, Naples |
| Death Place: | Royal Palace of Aranjuez, Aranjuez, Kingdom of Spain |
| Burial Place: | El Escorial |
Maria Antonia of Naples and Sicily (14 December 1784 21 May 1806) was the youngest surviving daughter of Ferdinand, King of Naples and Sicily, and Maria Carolina of Austria. As the wife of the future Ferdinand VII of Spain, then heir apparent to the Spanish throne, she held the title of Princess of Asturias. It is alleged that her mother-in-law, Maria Luisa of Parma, poisoned her, causing her death, but there is no evidence to prove this.
Born at the Caserta Palace in Caserta, Italy, Maria Antonia was the youngest daughter of King Ferdinand IV/III of Naples and Sicily and his first wife, Maria Carolina of Austria. Named after her mother's favorite sister, her maternal aunt Queen Marie Antoinette of France, she was an intelligent girl, having learned several languages by the age of seventeen .
In a series of dynastic alliances, Maria Antonia became engaged to her first cousin, Infante Ferdinand, Prince of Asturias (who later became King Ferdinand VII of Spain), while her eldest brother, Francis, became engaged to Infante Ferdinand's sister, Infanta Maria Isabella of Spain. On 6 October 1802, Maria Antonia married Infante Ferdinand in Barcelona, Spain.
The princess failed to provide the expected heir to the throne: her two pregnancies, in 1804 and 1805, ended in miscarriages. Her mother, Maria Carolina, was highly anti-French after the execution of her sister and brother-in-law during the French Revolution. She was also strongly opposed to the military expansion of the French republic. As Spain became more easily dominated by Napoleon Bonaparte, there were rumours that Maria Carolina wanted her daughter to poison the Queen of Spain and Manuel Godoy, Spain's prime minister. However, as with most poison rumours of the period, it is unlikely to be true, not least because both women were devout Roman Catholics and secondly because the Spanish court's ties to France were in no way greater or lesser than most in Europe's after Napoleon’s early victories. Maria Antonia's mother-in-law, Queen Maria Luisa, disliked her daughter-in-law and she encouraged rumours of a Habsburg poisoning plot, even subjecting her books and clothes to scrutiny in order to discredit her daughter-in-law further. In spite of all of this campaign of character assassination, Maria Antonia managed to gain considerable influence over her husband and created an opposition party against Queen Maria Luisa and Godoy.
Maria Antonia died of tuberculosis on 21 May 1806 at the Royal Palace of Aranjuez in Aranjuez, Spain, at the age of 21. It was rumoured that Maria Antonia had been poisoned by Queen Maria Luisa and Manuel Godoy but there is no evidence to support this claim. However, Queen Maria Carolina, who was devastated, truly believed this. Maria Antonia's father, King Ferdinand, consolidated Naples and Sicily into the Kingdom of the Two Sicilies a decade after her death.
The Neapolitan princess was buried at El Escorial in Spain. Her husband was to marry three more times: –