Margulis is a surname that, like its variants, is derived from the Ashkenazi Hebrew pronunciation of the Hebrew word Margalit (Israeli Hebrew pronounced as //maʁɡaˈlit//), meaning 'pearl.' Notable people and characters with the name include:
Berl Broder (born Margulis; 1817–1868), Broder singer
Dan Margulis (born 1951), author, expert on color correction and image retouching
