Margin of exposure explained

In toxicology, the margin of exposure (or MOE) of a substance is the ratio of its no-observed-adverse-effect level to its theoretical, predicted, or estimated dose or concentration of human intake.[1] It is used in risk assessment to determine the dangerousness of substances that are both genotoxic and carcinogenic.[2] This approach is preferred by both the World Health Organization and the European Food Safety Authority for the evaluation of the risk of carcinogens.[3]

Notes and References

  1. Benford. Diane. Bolger. P. Michael. Carthew. Philip. Coulet. Myriam. DiNovi. Michael. Leblanc. Jean-Charles. Renwick. Andrew G.. Setzer. Woodrow. Schlatter. Josef. Smith. Benjamin. Slob. Wout. Williams. Gary. Wildemann. Tanja. Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology. January 2010. 48. S2–S24. 10.1016/j.fct.2009.11.003. 20113851.
  2. Web site: Margin of Exposure approach developed by EFSA . EFSA . 20 November 2015.
  3. Lachenmeier. Dirk W.. Przybylski. Maria C.. Rehm. Jürgen. Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach. International Journal of Cancer. 15 September 2012. 131. 6. E995–E1003. 10.1002/ijc.27553. 22447328. 10.1.1.690.3319. 7021565.

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