Margaret Faul Explained

Margaret M. Faul
Alma Mater:University College Dublin, Harvard University
Thesis Year:1992
Doctoral Advisor:David A. Evans
Known For:Green chemistry, process science

Margaret M. Faul is an Irish American chemist and executive who has won multiple awards for innovations in process chemistry.

Background

Faul received her undergraduate degrees from University College, Dublin before embarking on doctoral studies with Professor David A. Evans at Harvard. Her studies focused mostly on metal-catalyzed nitrene transfer reactions[1] to produce aziridines, strained nitrogen precursors valued as pharmaceutical intermediates. Faul introduced multiple new wrinkles into this chemistry, including using chiral copper(I) catalysts[2] to produce enantiomerically-enriched aziridines, and using a variety of different nitrene sources for the transfer.

Research

Faul joined the process chemistry group at Eli Lilly in 1993, and joined Amgen's process group in 2003, rising eventually to its Executive Director. According to a biosketch at Organic Syntheses, Faul has expertise in Good Manufacturing Process scale-up of both chemical and biological therapeutics, and coordinates groups of external partners through licensing, regulatory, and program development issues.[3] She attributes much of Amgen's success in this area to early adoption of new technologies, such as supercritical carbon dioxide purification and ultra-high performance liquid chromatography (uPLC).[4]

Volunteer work

Faul is an Editorial Board member at Thieme journal Science of Synthesis.[5] She has served as the chair of the Enabling Technologies Consortium.[6] [7]

Awards and honors

Notes and References

  1. Evans. David A.. Bilodeau. Mark T.. Faul. Margaret M.. April 1994. Development of the Copper-Catalyzed Olefin Aziridination Reaction. Journal of the American Chemical Society. EN. 116. 7. 2742–2753. 10.1021/ja00086a007. 0002-7863.
  2. Evans. David A.. Faul. Margaret M.. Bilodeau. Mark T.. Anderson. Benjamin A.. Barnes. David M.. June 1993. Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins. Journal of the American Chemical Society. EN. 115. 12. 5328–5329. 10.1021/ja00065a068. 0002-7863.
  3. Faul. Margaret. 2017. Faul biosketch. Organic Syntheses. 2018-11-19. https://web.archive.org/web/20170721165631/http://www.orgsyn.org/content/pdfs/obits/margaretfaul.pdf. 2017-07-21. dead.
  4. Patel. Prachi. 2017-02-10. A Conversation with Margaret Faul. ACS Central Science. EN. 3. 2. 141–142. 10.1021/acscentsci.7b00050. 2374-7943. 5324089. 28280781.
  5. News: Science of Synthesis Editorial Board - Thieme Chemistry - Georg Thieme Verlag. Thieme. 2018-11-19. en-GB.
  6. News: Portrait of Dr. Margaret Faul - Thieme Chemistry - Georg Thieme Verlag KG. Thieme. 2018-11-19. en-GB.
  7. Web site: Working Groups. ETC. en-US. 2018-11-19. https://web.archive.org/web/20181119173539/http://www.etconsortium.org/working-groups/. 2018-11-19. dead.
  8. Web site: 2019 ACS Fellows. American Chemical Society. en. 2019-08-12.
  9. News: Women in Chemistry Award - Thieme Chemistry - Georg Thieme Verlag KG. Thieme. 2018-11-19. en-GB.
  10. Web site: Earle B. Barnes Award for Leadership in Chemical Research Management: Margaret M. Faul January 8, 2018 Issue - Vol. 96 Issue 2 Chemical & Engineering News. cen.acs.org. 2018-11-19.
  11. Web site: Amgen Wins the 2017 Green Chemistry Challenge Award. www.amgen.com. en. 2018-11-19.

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