| Marcellus High School | |
| Address: | 1 Mustang Hill |
| Zipcode: | 13108 |
| Country: | United States |
| Superintendent: | Michelle Brantner |
| Principal: | John R. Durkee |
| Enrollment: | 505 (2021-2022) |
| Teaching Staff: | 46.36 |
| Ratio: | 10.89 |
| Campus: | Rural |
| Mascot: | Mustangs |
| Colors: | Green, Black, Red and White |
| Yearbook: | Marcellian |
Marcellus High School is a public high school in Onondaga County, New York, United States. It is located in Marcellus, New York on the same campus as Marcellus Central School District's middle and elementary schools. Approximately 700 students attend the high school with over 65 teachers and staff members.
There are many courses offered at the high school with the option of doing other programs off-site. Some courses are offered through colleges/universities for dual credit. Some Advanced Placement (AP) courses are offered. Language courses include Spanish and French.