| Manuripi | |
| Map: | Rio Negro map.jpg |
| Subdivision Type1: | Countries |
| Subdivision Name1: | Bolivia, Peru |
| Subdivision Type3: | Regions |
| Subdivision Name3: | Madre de Dios Region (Peru); Pando Department (Bolivia) |
| Mouth: | Orthon River |
| Mouth Coordinates: | -11.1042°N -67.5592°W |
The Manuripi River is a river in Bolivia and Peru.