Manuele Zaccaria (died 1287/88) was the Genoese lord of Phocaea and its profitable alum mines, which he received as a fief from the Byzantine Emperor, from 1275 until his death in 1287/88. He was succeeded by his brother, Benedetto I Zaccaria.
His parents were Fulcone Zaccaria and one of his wives: Giulietta or Beatrice. Manuele married Clarisia Fieschi, and had four sons, Tedisio, Leonardo, Odoardo and Manfredo.
. William Miller (historian) . The Zaccaria of Phocaea and Chios (1275-1329) . 283–298 . Essays on the Latin Orient . Cambridge . Cambridge University Press . 1921 .