| Honorific-Prefix: | Most Reverend |
| Manuel de Mercado Aldrete | |
| Bishop of Panamá | |
| Church: | Catholic Church |
| Term: | 1576–1580 |
| Predecessor: | Francisco de Abrego |
| Successor: | Bartolomé de Ledesma |
| Consecration: | 1571 |
| Birth Place: | Spain |
| Death Date: | 4 April 1580 |
| Previous Post: | Bishop of Puerto Rico (1570–1576) |
| Nationality: | Spanish |
Manuel de Mercado Aldrete, O.S.H. (died 4 April 1580) was a Roman Catholic prelate who served as Bishop of Panamá (1576–1580)[1] and Bishop of Puerto Rico (1570–1576).[2] [3] [4]
Manuel de Mercado Aldrete was born in Spain and ordained a priest in the Order of Saint Jerome.[5] On February September 4, 1570, Pope Pius V, appointed him Bishop of Puerto Rico. In 1571, he was consecrated bishop by Cristóbal Rojas Sandoval, Archbishop of Seville. On March 28, 1576, Pope Gregory XIII, appointed him Bishop of Panamá. He served as Bishop of Panamá until his death on 4 April 1580.