| Manuel Rodrigues | |
| Fullname: | Manuel de Sousa Rodrigues |
| Birth Date: | 29 December 1942 |
| Birth Place: | Portugal |
| Position: | Defender |
| Clubs1: | Belenenses |
| Nationalyears1: | 1967 |
| Nationalteam1: | Portugal |
| Nationalcaps1: | 3 |
| Nationalgoals1: | 0 |
Manuel de Sousa Rodrigues (born 29 December 1942) is a former Portuguese footballer who played as a defender.