| Manuel Arzú | |
| Office: | Interim Governor of Nicaragua |
| Term Start: | 4 January 1825 |
| Term End: | 2 April 1825 |
| Predecessor: | José Anacleto Ordóñez |
| Successor: | Manuel Antonio de la Cerda |
| Birth Name: | Manuel Arzú y Delgado y Nájera |
| Birth Date: | 1775 |
| Birth Place: | New Spain |
| Death Place: | Guatemala City, Federal Republic of Central America |
| Nationality: | Mexican, Nicaraguan |
| Occupation: | Military officer |
| Allegiance: | Spanish Empire Mexican Empire Central America |
| Rank: | Colonel |
| Battles: |
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Manuel Arzú y Delgado y Nájera (1775 – 15 February 1835) was a Mexican and Nicaraguan military officer who held the position of interim governor of Nicaragua in 1825.
Manuel Arzú y Delgado y Nájera was born in 1775 in New Spain. He served for the Spanish Empire as a military officer.[1] In 1822, while serving for the First Mexican Empire, Arzú was placed in charge of a military force and was tasked with suppressing Salvadoran resistance to Mexican annexation. His forces captured San Salvador on 5 April 1822 and forced its defenders to abandon the city.[2]
In 1824, while serving for the Federal Republic of Central America, Arzú commanded federal soldiers to crush a rebellion in Nicaragua led by José Anacleto Ordóñez. After he crushed the rebellion, he was named as Nicaragua's interim governor from 4 January 1825 until 2 April 1825, when he was replaced with Manuel Antonio de la Cerda.[3]
He established Guatemala's first military academy.