| Manuel Antonio Warnes | |
| Order: | Alcalde of |
| Office: | Buenos Aires |
| Term Start: | 1775 |
| Term End: | 1776 |
| Predecessor: | Francisco Antonio Basavilbaso |
| Successor: | Ignacio de Irigoyen |
| Birth Date: | June 19, 1727 |
| Birth Place: | Cartagena de Indias |
| Death Date: | 1802 |
| Death Place: | Buenos Aires, Argentina |
| Birthname: | Manuel Antonio Warnes y Durango |
| Spouse: | María Josepha Arraez Ana Jacoba García de Zúñiga.. |
| Occupation: | Politician |
| Profession: | Army's officer |
| Signature: | Manuel Antonio Warnes, firma.jpg |
| Branch: | Spanish Army |
| Rank: | Captain |
Manuel Antonio Warnes y Durango (1727–1802) was a Spanish military man, who served as regidor and alcalde of Buenos Aires during the Viceroyalty of the Río de la Plata.
Warnes was born in Cartagena (Colombia), the son of Patricio Benito Warnes Geer and Juana María Durango y Atienza, belonging to a family of Irish, Flemish and Spanish origin. He had arrived in port of Buenos Aires from Cadiz as Master of the French frigate "Amable Maria". In 1756, he was appointed as alcalde of second vote (vice-mayor) of Buenos Aires, being designated alcalde in first vote in 1775 and 1788.
His great great grandfather was Salomón Warnes (born in Connacht), banished from Ireland for religious reasons, he had settled in Antwerp, at the beginning of the 17th century.