| Manuel Antonio Tocornal | |
| Birth Date: | 1817 6, df=y |
| Birth Place: | Santiago, Chile |
| Death Place: | Santiago, Chile |
| Nationality: | Chilean |
| Office1: | President of the Senate of the Republic of Chile |
| Term Start1: | 3 June 1867 |
| Term End1: | 15 August 1867 |
| Predecessor1: | José Rafael Larraín |
| Successor1: | Juan de Dios Correa de Saa |
| Party: | Conservative Party |
| Occupation: | Politician |
| Profession: | Lawyer |
| Parents: | Joaquín Tocornal |
Manuel Antonio Tocornal Grez (born 12 June 1817 – 15 August 1867) was a Chilean politician who served as President of the Senate of Chile. In 1866–1867, he was rector of the University of Chile.