| Manuel | |
| Hereditary Prince of Portugal | |
| House: | Aviz |
| Father: | John III of Portugal |
| Mother: | Catherine of Austria |
| Birth Date: | 11 November 1531 |
| Birth Place: | Alvito, Kingdom of Portugal |
| Death Date: | 14 April 1537 (age 5) |
| Death Place: | Évora, Kingdom of Portugal |
Manuel (11 November 1531 – 14 April 1537), was the Hereditary Prince of Portugal from 1535 to his death in 1537. He was the fifth child and second son of king John III of Portugal and Catherine of Austria.
In 1535, his father officially designated him as Prince of Portugal, taking the place of his eldest sister Infanta Maria Manuela. However, after his premature death at five years old, his younger brother Infante Filipe became the next Prince of Portugal.