Mantle zone explained

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.^[1]

It is also known as the "corona".^[2]

It contains transient lymphocytes.^[3]

It is the location of the lymphoma in mantle cell lymphoma.

Pathology

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.

External links

• https://web.archive.org/web/20080813003821/http://erl.pathology.iupui.edu/HISTO/LABE109.HTM
•  — "Lymphoid Tissues and Organs: lymph node, cortex and medulla"

Notes and References

1. Web site: University of Cambridge: Department of Pathology . 2008-07-29 . dead . https://web.archive.org/web/20080603110413/http://teaching.path.cam.ac.uk/partIB_pract/P05/ . 2008-06-03 .
2. Web site: Lymph Nodes . 2008-07-29 . dead . https://web.archive.org/web/20080317074847/http://www3.umdnj.edu/histsweb/lab12/lab12nodes.html . 2008-03-17 .
3. Web site: Pathology of lymph nodes – Dr. Levy . www.dartmouth.edu . dead . https://web.archive.org/web/19991105133631/http://www.dartmouth.edu/~nlevy/levylecture.html . 1999-11-05.