| Manny Castillo | |
| Position: | Third baseman |
| Birth Date: | 1 April 1957 |
| Birth Place: | Santo Domingo, Dominican Republic |
| Bats: | Switch |
| Throws: | Right |
| Debutleague: | MLB |
| Debutdate: | September 1 |
| Debutyear: | 1980 |
| Debutteam: | Kansas City Royals |
| Finalleague: | MLB |
| Finaldate: | October 2 |
| Finalyear: | 1983 |
| Finalteam: | Seattle Mariners |
| Statleague: | MLB |
| Stat1label: | Batting average |
| Stat1value: | .242 |
| Stat2label: | Home runs |
| Stat2value: | 3 |
| Stat3label: | Runs batted in |
| Stat3value: | 73 |
| Teams: | |
Esteban Manuel Antonio Castillo Cabrera (born April 1, 1957) is a Dominican former Major League Baseball third baseman. He batted and threw right-handed, and was 5 foot 9. Castillo played 3 seasons in Major League Baseball, with the Kansas City Royals in and the Seattle Mariners in and . He played in 236 games in his career, with a batting average of .242 with 174 hits in 719 at-bats. He had 3 stolen bases, 3 home runs, 73 RBI and 63 runs.
Castillo had his best season in 1982 with the Mariners when he had 130 hits, had an average of .257, and all 3 of his career home runs.
As of 2018, Castillo is a coach in the Tampa Bay Rays farm system.