Mannosylglycerate hydrolase explained

Mannosylglycerate hydrolase
Ec Number:	3.2.1.170

Mannosylglycerate hydrolase (2-O-(6-phospho-mannosyl)-D-glycerate hydrolase, alpha-mannosidase, mngB (gene)) is an enzyme with systematic name 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate acylhydrolase.^[1] This enzyme catalyses the following chemical reaction

2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H₂O

\rightleftharpoons

D-mannose 6-phosphate + D-glycerate

The enzyme participates in the mannosylglycerate degradation pathway of some bacteria.

Notes and References

Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO . Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor . The Journal of Biological Chemistry . 279 . 7 . 5537–48 . February 2004 . 14645248 . 10.1074/jbc.m310980200 . free .