Mannitol-1-phosphate 5-dehydrogenase explained

mannitol-1-phosphate 5-dehydrogenase
Ec Number:	1.1.1.17
Cas Number:	9028-24-4
Go Code:	0008926

In enzymology, a mannitol-1-phosphate 5-dehydrogenase is an enzyme that catalyzes the chemical reaction

D-mannitol 1-phosphate + NAD⁺

\rightleftharpoons D-fructose 6-phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NAD⁺, whereas its 3 products are fructose 6-phosphate, NADH and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.

See also

• D-Mannitol

References

• Marmur J, Hotchkiss RD . 1955 . Mannitol metabolism, a transferable property of pneumococcus . J. Biol. Chem. . 214 . 383 - 96 . 14367396 . 1 . 10.1016/S0021-9258(18)70976-9 . free .
• Book: Wolfe JB . Kaplan NO . 1955 . Wolff . Johnb . Nathano . Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli . Methods Enzymol. . 1 . 346 - 348 . 10.1016/0076-6879(55)01050-1 . Kaplan .
• Wolfe JB . Kaplan NO . 1956 . D-Mannitol 1-phosphate dehydrogenase from Escherichia coli . J. Biol. Chem. . 218 . 2 . 849 - 869 . 10.1016/S0021-9258(18)65848-X . free . 13295236 .