| Province: | MB |
| Type: | PR |
| Route: | 251 |
| Established: | 1966 |
| Length Km: | 55.7 |
| Direction A: | West |
| Terminus A: | near the Antler-Lyleton Border Crossing |
| Junction: |
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| Direction B: | East |
| Terminus B: | near Goodlands |
| Rural Municipalities: | Two Borders, Brenda-Waskada, Deloraine-Winchester |
| Previous Type: | PR |
| Previous Route: | 250 |
| Next Type: | PR |
| Next Route: | 252 |
Provincial Road 251 (PR 251) is a 55.7adj=midNaNadj=mid east–west highway in the Westman Region of Manitoba. It serves as the primary road access to the hamlets of Lyleton, Coulter, Waskada, and Goodlands in the very southwest corner of the province.
PR 251 begins in the Municipality of Two Borders at an intersection with PR 256, north of the Antler-Lyleton Border Crossing. It heads east through rural areas for several kilometres, passing through the Lyleton community along Railway Avenue before joining Provincial Trunk Highway 83 (PTH 83) in a short concurrency (overlap). The highway now crosses the Antler River and travels past the Linear Mounds National Historic Site before passing through the hamlet of Coulter and crossing the Souris River.
PR 251 enters the Municipality of Brenda-Waskada after several kilometres of rural farmland, immediately making a sharp left turn as it enters the town of Waskada. It travels through the centre of town along Park Street, clipping the western edge of downtown at an intersection with Railway Avenue. After passing through neighbourhoods, the highway makes a sharp right at a junction with PR 452 before leaving Waskada and continuing east through rural farmland. PR 251 has an intersection with the southern end of PR 254 and travels along the northern edge of Goodlands before coming to an end along the border with the Municipality of Deloraine-Winchester at an intersection with PTH 21. The entire length of PR 251 is a paved, two-lane highway.[1]