| Manicorezinho River | |
| Pushpin Map: | Brazil |
| River System: | Manicoré River |
| Source1 Location: | Amazonas state |
| Mouth Location: | Manicoré River |
| Mouth Coordinates: | -6.9372°N -61.061°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Manicorezinho River is a river of Amazonas state in north-western Brazil, a tributary of the Manicoré River.
The river flows through the Manicoré Biological Reserve, created by decree in May 2016 in the week before the provisional removal of president Dilma Rousseff.The reserve was created in part to preserve the biodiversity of the Manicorezinho.