| Manicoré River | |
| Pushpin Map: | Brazil |
| River System: | Madeira River |
| Source1 Location: | Amazonas state |
| Mouth Coordinates: | -5.8589°N -61.3287°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
| Length: | 390[1] |
| Tributaries Right: | Manicorezinho, Jatuarana |
Manicoré River (Portuguese: Rio Manicoré) is a river of Amazonas state in north-western Brazil. It is a tributary of the Madeira River and merges into this river about 3km (02miles) upstream from the town of Manicoré.
The headwaters of the river are in the Campos Amazônicos National Park, a protected area created in 2006 that holds an unusual enclave of cerrado vegetation in the Amazon rainforest.Further north the river defines part of the eastern boundary of the Campos de Manicoré Environmental Protection Area, created in April 2016 just before the provisional removal of president Dilma Rousseff.It then flows through the Manicoré Biological Reserve, which was created at the same time.